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Doe

Sat, Mar-20-04, 19:13

Nat Rev Drug Discov. 2004 Mar;3(3):205-14. Links

Neurodegenerative diseases and oxidative stress.

Barnham KJ, Masters CL, Bush AI.

Department of Pathology, The University of Melbourne, and The
Mental Health Research Institute of Victoria, Victoria 3010,
Australia.

Oxidative stress has been implicated in the progression of
Alzheimer's disease, Parkinson's disease and amyotrophic
lateral sclerosis. Oxygen is vital for life but is also
potentially dangerous, and a complex system of checks and
balances exists for utilizing this essential element.
Oxidative stress is the result of an imbalance in
pro-oxidant/antioxidant homeostasis that leads to the
generation of toxic reactive oxygen species. The systems in
place to cope with the biochemistry of oxygen are complex, and
many questions about the mechanisms of oxygen regulation
remain unanswered. However, this same complexity provides a
number of therapeutic targets, and different strategies,
including novel metal-protein attenuating compounds, aimed at
a variety of targets have shown promise in clinical studies.

PMID: 15031734 [PubMed - in process]

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Who loves ya. Tom Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
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markd

Sun, Mar-21-04, 06:11

I think it more likely that the research into cholesterol
related amyloid plaque formation will provide the key in these
disorders, the antioxidants coming in to do second line
antiinflamation duty and not primary control.

>Nat Rev Drug Discov. 2004 Mar;3(3):205-14. Links
>
>
>Neurodegenerative diseases and oxidative stress.
>
>Barnham KJ, Masters CL, Bush AI.
>
>Department of Pathology, The University of Melbourne, and The
>Mental Health Research Institute of Victoria, Victoria 3010,
>Australia.
>
>Oxidative stress has been implicated in the progression of
>Alzheimer's disease, Parkinson's disease and amyotrophic
>lateral sclerosis. Oxygen is vital for life but is also
>potentially dangerous, and a complex system of checks and
>balances exists for utilizing this essential element.
>Oxidative stress is the result of an imbalance in
>pro-oxidant/antioxidant homeostasis that leads to the
>generation of toxic reactive oxygen species. The systems in
>place to cope with the biochemistry of oxygen are complex,
>and many questions about the mechanisms of oxygen regulation
>remain unanswered. However, this same complexity provides a
>number of therapeutic targets, and different strategies,
>including novel metal-protein attenuating compounds, aimed at
>a variety of targets have shown promise in clinical studies.
>
>PMID: 15031734 [PubMed - in process]
>
>-------------------------------------------------------------
>--------------
>------
>
>Who loves ya. Tom Jesus Was A Vegetarian!
>http://jesuswasavegetarian.7h.com Man Is A Herbivore!
>http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
>PEOPLE WALKING
>http://pages.ivillage.com/ironjustice/deadpeoplewalking