Biotin and metformin (Glucophage)

[PineSlayer]

I read SimplyDawn's post on biotin and it read, in part:

"Biotin has been found to stimulate glucokinase, an enzyme in the liver, resulting in increased synthesis of glycogen (http://lpi.oregonstate.edu/infocenter/glossary.html#glycogen), the storage form of glucose. Biotin has also been found to stimulate the secretion of insulin (http://lpi.oregonstate.edu/infocenter/glossary.html#insulin) in the pancreas of rats, "

I'm taking metformin, the generic for Glucophage. This supresses the production of glucose by the liver. Also, if biotin stimulates insulin release, it seems to me that it would be counter-productive for ALL of us.

Could someone clear this up for me, either from personal experience or a quote from research?

Thanks very much!

[nopie]

from Encyclopedia of Nutritional Supplements by Michael T Murray:

Biotin supplementation enhances insulin sensitivity and increases the activity of the enzyme glucokinase. Glucokinase is the enzyme responsible for the first step in the utilization of glucose by the liver. Glucokinase concentrations in diabetics are very low. Evidently, supplementing the diet with high doses of biotin improves glucokinase activity and glucose metabolism in diabetics. In one study, supplementation of 16 milligrams of biotin per day resulted in significant lowering of fasting blood sugar levels and improvements in blood glucose control in type 1 diabetics. In a study of type 2 diabetics, similar effects were noted with 9 milligrams of biotin per day. High-dose biotin is also very helpful in the treatment of severe diabetic nerve disease (diabetic neuropathy).