Alzheimer's prevention diet: comment on this family's strategies?

[Matt]

Hello,

My aunt has compiled the following "rules of thumb" that my
family uses for our Alzheimer's prevention diet. Can anyone
comment on these points and/or possibly point to other places
of reference so that we can possibly learn more, maybe read
about other perspectives/opinions on Alzheimer's prevention
with diet? Are there other steps we might take above and
beyond what is listed below?

(My grandmother and great-grandmother have experienced
Alzheimer's, so my family is quite sensitive and aware of any
reasonable prevention measures that we can take.)

-Matt

[[ My aunt's compilation follows... ]]

I've listed my prevention strategies in order of my
perceived importance. These are not proven to inhibit the
disease, but they are good health practices anyway….so what
do you have to lose?

1. Choline - This amino acid improves neuro-transmission
in the memory portion of the brain. One of the reason
that Grandma took the drug Aricept was to increase the
choline production in the brain.

Choline can be found in eggs, green leafy vegetables, legumes,
and tofu. You can also by it in capsule form. There is no set
daily dosage requirement.

2. Vitamin E - A powerful anti-oxidant believed to be the
most important of all vitamins in preventing
Alzheimer's. Most research supports taking well above
the daily recommended dosage. I take 1,000
mg. twice a day.

3. Vitamin C - Useful in the development of new brain
cells which slows down at the onset of Alzheimer's.
Again research suggests a higher than normal dosage. I
take 1,000 mg. three times a day.

4. Fish oils - Omega 3 fatty acids are rich in fish oils.
The highest dosage is found in sardines, salmon, tuna
and turbot. You should be having a minimum of two
servings per week. I take an fatty acid supplement
three times a day that contains both Omega 3 and 6.
Not only has it been found to improve brain
efficiency, but it also maintains good joint health
and helps guard cholesterol levels.

5. Homocysteine level in Blood - The higher the level of
homocysteine, the more likely you are to develop the
disease. Homocysteines has a toxic effect on brain
cells that can begin to age the brain long before
Alzheimer's sets in. A blood test can tell you if your
levels are elevated. Take 2 mg. of folic acid to keep
them under control. This is more than typically found
in your daily multivitamin.

6. Aluminum - Avoid ingesting it. Aluminum shows up in
the autopsies of Alzheimer's victims' brains. There
toxic properties may contribute to the destruction of
brain cells. Minimize your use of soda cans and
aluminum cook ware. Watch for traces of harmful metals
in your antacid and other over-the-counter drugs.

7. Ibuprofen - This in the most controversial of the
recommendations I am making to you. This is because
regular use of Important may lead to liver and kidney
damage, as well as irritate your stomach lining.
Nonetheless, inflammation is also believed to play a
big factor in Alzheimer's. The swelling of the brain
membranes is believed to play a part in the
development of amyloid plaques in the brain.

I take one 200 mg. tablet twice a day for several months, then
alternate its use with an herbal supplement alternative. It is
called Zyflamend from New Chapter. The herb is not only
unproven, but more expensive than taking Advil. It is much
fewer side effects, however.

8. Deep breathing - Oxygen to the brain is critically
important to normal reticular activity that keeps your
brain alert. Aerobic exercise, yoga or pilates are
great ways to meet this need.

9. Water - Dehydration effects proper brain function, and
most of us walk around in this condition every day
without even realizing it. I keep a water bottle with
me almost everywhere I go and drink one full bottle
first thing every morning.

Hope this helps. For more information you may log onto the
Alzheimer's website at www.ALZ.org. The is some incredibly
promising research out there using passive immunization of
Beta Amyloids that are believed to be the primary cause of the
disease. There are also a new advances in slowing down the
disease through stimulation of nerve growth factors in the
brain. Not much can be done at present until symptoms arise in
the victim. Many researchers believe that the damage begins in
the brain up to 20 years before these symptoms first occur.
For this reason, it is none to soon for each of you to take a
pro-active stance in your own personal prevention of the
disease. I already give [my children that are 11 and 14] extra
E and C and a choline supplement. They seldom drink soda or
other canned drinks and I try to push the water as much as I
can. I just can't see a down side to forming good habits now.
--
Remove the obvious text (including the dash) to email me.

[munk]

Matt:

I have been under the care of my neurologist for nearly three
years now for Early Onset Alzheimer's Disease. I am 54 years
old and I think that I have had every test known to man for my
condition. For the last year, my doctors have had me on a
regimen of the following:

Reminyl 12 mg twice daily Vitamin E 1000 mg twice daily
Vitamin C 1000 mg twice daily Ibuprofen (Advil) 500 mg nightly

On my own I take (but they do not object), the following:

Shark's Liver Oil gel capsules found at GNC

I drink at least two (2) bottles of tonic water a day for leg
cramps for the quinine in it. My doctors advises that quinine
tablets were too much but tonic water was much better. Plus, I
drink lots of water.

I keep my brain very active by doing plenty of puzzles daily
and trying to learn something new every day. I walk daily even
when I really don't want to get out.

During the last three months, I have seen a considerable
improvement in my condition. Where I would not leave the house
unaccompanied by one of my family members, I am now driving
again. I am remembering things even my husband is forgetting.

I am due for another MRI and tests this month and, hopefully,
it will not show near the amount of brain atrophy that it did
last year. Maybe this regimen does work but only time will
tell. I am thankful for the time being that it is working for
me, and that it has given me somemore time to enjoy my family.

Kathy

"Matt" <matt@downwithspammers-mengland.net> wrote in message
news:kh7r10h2ou9lcte01l8mb3v3tgokcs3eh2@4ax.com...
> Hello,
>
> My aunt has compiled the following "rules of thumb" that my
> family uses for our Alzheimer's prevention diet. Can anyone
> comment on these points and/or possibly point to other
> places of reference so that we can possibly learn more,
> maybe read about other perspectives/opinions on Alzheimer's
> prevention with diet? Are there other steps we might take
> above and beyond what is listed below?
>
> (My grandmother and great-grandmother have experienced
> Alzheimer's, so my family is quite sensitive and aware of
> any reasonable prevention measures that we can take.)
>
> -Matt
>
> [[ My aunt's compilation follows... ]]
>
> I've listed my prevention strategies in order of my
> perceived importance. These are not proven to inhibit the
> disease, but they are good health practices anyway..so what
> do you have to lose?
>
> 1. Choline - This amino acid improves neuro-transmission in
> the memory portion of the brain. One of the reason that
> Grandma took the drug Aricept was to increase the choline
> production in the brain.
>
> Choline can be found in eggs, green leafy vegetables,
> legumes, and tofu. You can also by it in capsule form. There
> is no set daily dosage requirement.
>
> 2. Vitamin E - A powerful anti-oxidant believed to be the
> most important of all vitamins in preventing Alzheimer's.
> Most research supports taking well above the daily
> recommended dosage. I take 1,000
> mg. twice a day.
>
> 3. Vitamin C - Useful in the development of new brain cells
> which slows down at the onset of Alzheimer's. Again
> research suggests a higher than normal dosage. I take
> 1,000 mg. three times a day.
>
> 4. Fish oils - Omega 3 fatty acids are rich in fish oils.
> The highest dosage is found in sardines, salmon, tuna and
> turbot. You should be having a minimum of two servings
> per week. I take an fatty acid supplement three times a
> day that contains both Omega 3 and 6. Not only has it
> been found to improve brain efficiency, but it also
> maintains good joint health and helps guard cholesterol
> levels.
>
> 5. Homocysteine level in Blood - The higher the level of
> homocysteine, the more likely you are to develop the
> disease. Homocysteines has a toxic effect on brain cells
> that can begin to age the brain long before Alzheimer's
> sets in. A blood test can tell you if your levels are
> elevated. Take 2 mg. of folic acid to keep them under
> control. This is more than typically found in your daily
> multivitamin.
>
> 6. Aluminum - Avoid ingesting it. Aluminum shows up in the
> autopsies of Alzheimer's victims' brains. There toxic
> properties may contribute to the destruction of brain
> cells. Minimize your use of soda cans and aluminum cook
> ware. Watch for traces of harmful metals in your antacid
> and other over-the-counter drugs.
>
> 7. Ibuprofen - This in the most controversial of the
> recommendations I am making to you. This is because
> regular use of Important may lead to liver and kidney
> damage, as well as irritate your stomach lining.
> Nonetheless, inflammation is also believed to play a big
> factor in Alzheimer's. The swelling of the brain
> membranes is believed to play a part in the development
> of amyloid plaques in the brain.
>
> I take one 200 mg. tablet twice a day for several months,
> then alternate its use with an herbal supplement
> alternative. It is called Zyflamend from New Chapter. The
> herb is not only unproven, but more expensive than taking
> Advil. It is much fewer side effects, however.
>
> 8. Deep breathing - Oxygen to the brain is critically
> important to normal reticular activity that keeps your
> brain alert. Aerobic exercise, yoga or pilates are great
> ways to meet this need.
>
> 9. Water - Dehydration effects proper brain function, and
> most of us walk around in this condition every day
> without even realizing it. I keep a water bottle with me
> almost everywhere I go and drink one full bottle first
> thing every morning.
>
> Hope this helps. For more information you may log onto the
> Alzheimer's website at www.ALZ.org. The is some incredibly
> promising research out there using passive immunization of
> Beta Amyloids that are believed to be the primary cause of
> the disease. There are also a new advances in slowing down
> the disease through stimulation of nerve growth factors in
> the brain. Not much can be done at present until symptoms
> arise in the victim. Many researchers believe that the
> damage begins in the brain up to 20 years before these
> symptoms first occur. For this reason, it is none to soon
> for each of you to take a pro-active stance in your own
> personal prevention of the disease. I already give [my
> children that are 11 and 14] extra E and C and a choline
> supplement. They seldom drink soda or other canned drinks
> and I try to push the water as much as I can. I just can't
> see a down side to forming good habits now.
> --
> Remove the obvious text (including the dash) to email me.

[Matti Nark]

Mon, 02 Feb 2004 01:05:49 GMT in article
<kh7r10h2ou9lcte01l8mb3v3tgokcs3eh2@4ax.com> Matt
<matt@downwithspammers-mengland.net> wrote:

>Hello,
>
>My aunt has compiled the following "rules of thumb" that my
>family uses for our Alzheimer's prevention diet. Can anyone
>comment on these points and/or possibly point to other places
>of reference so that we can possibly learn more, maybe read
>about other perspectives/opinions on Alzheimer's prevention
>with diet? Are there other steps we might take above and
>beyond what is listed below?
>
>(My grandmother and great-grandmother have experienced
>Alzheimer's, so my family is quite sensitive and aware of any
>reasonable prevention measures that we can take.)
>
>-Matt
>
>[[ My aunt's compilation follows... ]]
>
There are some interesting studies about Salvia
lavandulaefolia (Spanish Sage). And what's the current status
of Ginkgo biloba?. I know that the results of the trials have
been conflicting since the early successes, but perhaps it may
be worth trying together with other supplements. Some other
supplements possibly worth considering: acetyl-L-carnitine,
alpha-lipoic acid, phosphatidylserine and melatonin.

--
Matti Narkia

[Capitalist]

On Mon, 02 Feb 2004 01:05:49 GMT, Matt
<matt@downwithspammers-mengland.net> wrote:
>
>My aunt has compiled the following "rules of thumb" that my
>family uses for our Alzheimer's prevention diet. Can anyone
>comment on these points and/or possibly point to other places
>of reference so that we can possibly learn more, maybe read
>about other perspectives/opinions on Alzheimer's prevention
>with diet? Are there other steps we might take above and
>beyond what is listed below?
>

Have you had the chance to look at LEF's protocol?

http://www.lef.org/protocols/prtcl-006.shtml

[Tim Tyler]

Matt <matt@downwithspammers-mengland.net> wrote or quoted:

> My aunt has compiled the following "rules of thumb" that my
> family uses for our Alzheimer's prevention diet. Can anyone
> comment on these points and/or possibly point to other
> places of reference so that we can possibly learn more,
> maybe read about other perspectives/opinions on Alzheimer's
> prevention with diet? Are there other steps we might take
> above and beyond what is listed below?

Consider going easy on the cake:

``Dietary restriction and 2-deoxyglucose administration
improve behavioral outcome and reduce degeneration of
dopaminergic neurons in models of Parkinson's disease''

- http://calorierestriction.org/pmid/?n=10398297

``Dietary restriction retards the age-associated loss of rat
striatal dopaminergic receptors''

- http://calorierestriction.org/pmid/?n=7291993

``Food restriction reduces brain damage and improves
behavioral outcome following excitotoxic and metabolic
insults''

- http://calorierestriction.org/pmid/?n=9894871

``Dietary restriction protects hippocampal neurons against the
death-promoting action of a presenilin-1 mutation''

- http://calorierestriction.org/pmid/?n=10526115

``Dietary restriction increases the number of newly generated
neural
cells, and induces BDNF expression, in the dentate gyrus of
rats''

- http://calorierestriction.org/pmid/?n=11220789

...and maybe on the isoquinolines:

``Presence of tetrahydroisoquinoline and
1-methyl-tetrahydro- isoquinoline in foods: compounds
related to Parkinson's disease''

- http://calorierestriction.org/pmid/?n=3398705

``Endogenous risk factors in Parkinson's disease: dopamine and
tetrahydroisoquinolines''

- http://calorierestriction.org/pmid/?n=12866710

``Tetrahydroisoquinoline derivatives as possible Parkinson's
disease-inducing substances''

- http://calorierestriction.org/pmid/?n=1244014

``Role of noradrenergic system in the mechanism of action of
endogenous neurotoxin 1,2,3,4-tetrahydroisoquinoline:
biochemical and functional studies.''

- http://calorierestriction.org/pmid/?n=12020040

``Dopamine-derived endogenous N-methyl-(R)-salsolinol: its
role in Parkinson's disease''

- http://calorierestriction.org/pmid/?n=12200189

``In vitro pharmacological activity of the
tetrahydroisoquinoline salsolinol present in products from
Theobroma cacao L. like cocoa and chocolate''

- http://calorierestriction.org/pmid/?n=11025151
--
__________
|im |yler http://timtyler.org/ tim@tt1lock.org Remove
lock to reply.

[Matti Nark]

Mon, 02 Feb 2004 04:09:57 +0200 in article
<7uar10p3c09i46ca8fcn19d8irnf30gmqe@4ax.com> Matti Narkia
<mnng@despammed.com> wrote:

>Mon, 02 Feb 2004 01:05:49 GMT in article
><kh7r10h2ou9lcte01l8mb3v3tgokcs3eh2@4ax.com> Matt
><matt@downwithspammers-mengland.net> wrote:
>
>>Hello,
>>
>>My aunt has compiled the following "rules of thumb" that my
>>family uses for our Alzheimer's prevention diet. Can anyone
>>comment on these points and/or possibly point to other
>>places of reference so that we can possibly learn more,
>>maybe read about other perspectives/opinions on Alzheimer's
>>prevention with diet? Are there other steps we might take
>>above and beyond what is listed below?
>>
>>(My grandmother and great-grandmother have experienced
>>Alzheimer's, so my family is quite sensitive and aware of
>>any reasonable prevention measures that we can take.)
>>
>>-Matt
>>
>>[[ My aunt's compilation follows... ]]
>>
>There are some interesting studies about Salvia
>lavandulaefolia (Spanish Sage). And what's the current status
>of Ginkgo biloba?. I know that the results of the trials have
>been conflicting since the early successes, but perhaps it
>may be worth trying together with other supplements. Some
>other supplements possibly worth considering:
>acetyl-L-carnitine, alpha-lipoic acid, phosphatidylserine and
>melatonin.

Perhaps also curcumin and some other substances from
Curcuma longa.

--
Matti Narkia

[John De Ho]

Matti Narkia wrote...

> >[[ My aunt's compilation follows... ]]
> >
> There are some interesting studies about Salvia
> lavandulaefolia (Spanish Sage). And what's the current
> status of Ginkgo biloba?. I know that the results of the
> trials have been conflicting since the early successes, but
> perhaps it may be worth trying together with other
> supplements. Some other supplements possibly worth
> considering: acetyl-L-carnitine, alpha-lipoic acid,
> phosphatidylserine and melatonin.

I'm surprised not to see B12 (as methylcobalamin, 500-1500
micrograms per day) and betaine. B12 works well with folic
acid to reduce homocysteine, and betaine has been shown to
reduce homocysteine dramatically.

--
John de Hoog http://dehoog.org

[Ignoramus4]

I would be greatly interested if you posted updates once in a
while, of course if you do not forget:)

I wish you well!

i

In article <GbiTb.1978$QU1.1673@fe2.texas.rr.com>,
<munk@houston.rr.com> wrote:
> Matt:
>
> I have been under the care of my neurologist for nearly
> three years now for Early Onset Alzheimer's Disease. I am 54
> years old and I think that I have had every test known to
> man for my condition. For the last year, my doctors have had
> me on a regimen of the following:
>
> Reminyl 12 mg twice daily Vitamin E 1000 mg twice
> daily Vitamin C 1000 mg twice daily Ibuprofen (Advil)
> 500 mg nightly
>
> On my own I take (but they do not object), the following:
>
> Shark's Liver Oil gel capsules found at GNC
>
> I drink at least two (2) bottles of tonic water a day for
> leg cramps for the quinine in it. My doctors advises that
> quinine tablets were too much but tonic water was much
> better. Plus, I drink lots of water.
>
> I keep my brain very active by doing plenty of puzzles daily
> and trying to learn something new every day. I walk daily
> even when I really don't want to get out.
>
> During the last three months, I have seen a considerable
> improvement in my condition. Where I would not leave the
> house unaccompanied by one of my family members, I am now
> driving again. I am remembering things even my husband is
> forgetting.
>
> I am due for another MRI and tests this month and,
> hopefully, it will not show near the amount of brain atrophy
> that it did last year. Maybe this regimen does work but only
> time will tell. I am thankful for the time being that it is
> working for me, and that it has given me somemore time to
> enjoy my family.
>
> Kathy
>
>
> "Matt" <matt@downwithspammers-mengland.net> wrote in message
> news:kh7r10h2ou9lcte01l8mb3v3tgokcs3eh2@4ax.com...
>> Hello,
>>
>> My aunt has compiled the following "rules of thumb" that my
>> family uses for our Alzheimer's prevention diet. Can anyone
>> comment on these points and/or possibly point to other
>> places of reference so that we can possibly learn more,
>> maybe read about other perspectives/opinions on Alzheimer's
>> prevention with diet? Are there other steps we might take
>> above and beyond what is listed below?
>>
>> (My grandmother and great-grandmother have experienced
>> Alzheimer's, so my family is quite sensitive and aware of
>> any reasonable prevention measures that we can take.)
>>
>> -Matt
>>
>> [[ My aunt's compilation follows... ]]
>>
>> I've listed my prevention strategies in order of my
>> perceived importance. These are not proven to inhibit the
>> disease, but they are good health practices anyway..so what
>> do you have to lose?
>>
>> 1. Choline - This amino acid improves neuro-transmission in
>> the memory portion of the brain. One of the reason that
>> Grandma took the drug Aricept was to increase the
>> choline production in the brain.
>>
>> Choline can be found in eggs, green leafy vegetables,
>> legumes, and tofu. You can also by it in capsule form.
>> There is no set daily dosage requirement.
>>
>> 2. Vitamin E - A powerful anti-oxidant believed to be the
>> most important of all vitamins in preventing
>> Alzheimer's. Most research supports taking well above
>> the daily recommended dosage. I take 1,000
>> mg. twice a day.
>>
>> 3. Vitamin C - Useful in the development of new brain cells
>> which slows down at the onset of Alzheimer's. Again
>> research suggests a higher than normal dosage. I take
>> 1,000 mg. three times a day.
>>
>> 4. Fish oils - Omega 3 fatty acids are rich in fish oils.
>> The highest dosage is found in sardines, salmon, tuna
>> and turbot. You should be having a minimum of two
>> servings per week. I take an fatty acid supplement three
>> times a day that contains both Omega 3 and 6. Not only
>> has it been found to improve brain efficiency, but it
>> also maintains good joint health and helps guard
>> cholesterol levels.
>>
>> 5. Homocysteine level in Blood - The higher the level of
>> homocysteine, the more likely you are to develop the
>> disease. Homocysteines has a toxic effect on brain cells
>> that can begin to age the brain long before Alzheimer's
>> sets in. A blood test can tell you if your levels are
>> elevated. Take 2 mg. of folic acid to keep them under
>> control. This is more than typically found in your daily
>> multivitamin.
>>
>> 6. Aluminum - Avoid ingesting it. Aluminum shows up in the
>> autopsies of Alzheimer's victims' brains. There toxic
>> properties may contribute to the destruction of brain
>> cells. Minimize your use of soda cans and aluminum cook
>> ware. Watch for traces of harmful metals in your antacid
>> and other over-the-counter drugs.
>>
>> 7. Ibuprofen - This in the most controversial of the
>> recommendations I am making to you. This is because
>> regular use of Important may lead to liver and kidney
>> damage, as well as irritate your stomach lining.
>> Nonetheless, inflammation is also believed to play a big
>> factor in Alzheimer's. The swelling of the brain
>> membranes is believed to play a part in the development
>> of amyloid plaques in the brain.
>>
>> I take one 200 mg. tablet twice a day for several months,
>> then alternate its use with an herbal supplement
>> alternative. It is called Zyflamend from New Chapter. The
>> herb is not only unproven, but more expensive than taking
>> Advil. It is much fewer side effects, however.
>>
>> 8. Deep breathing - Oxygen to the brain is critically
>> important to normal reticular activity that keeps your
>> brain alert. Aerobic exercise, yoga or pilates are great
>> ways to meet this need.
>>
>> 9. Water - Dehydration effects proper brain function, and
>> most of us walk around in this condition every day
>> without even realizing it. I keep a water bottle with me
>> almost everywhere I go and drink one full bottle first
>> thing every morning.
>>
>> Hope this helps. For more information you may log onto the
>> Alzheimer's website at www.ALZ.org. The is some incredibly
>> promising research out there using passive immunization of
>> Beta Amyloids that are believed to be the primary cause of
>> the disease. There are also a new advances in slowing down
>> the disease through stimulation of nerve growth factors in
>> the brain. Not much can be done at present until symptoms
>> arise in the victim. Many researchers believe that the
>> damage begins in the brain up to 20 years before these
>> symptoms first occur. For this reason, it is none to soon
>> for each of you to take a pro-active stance in your own
>> personal prevention of the disease. I already give [my
>> children that are 11 and 14] extra E and C and a choline
>> supplement. They seldom drink soda or other canned drinks
>> and I try to push the water as much as I can. I just can't
>> see a down side to forming good habits now.

[Michaelpri]

John de Hoog wrote

> I'm surprised not to see B12 (as methylcobalamin, 500-1500
> micrograms per day) and betaine. B12 works well with folic
> acid to reduce homocysteine, and betaine has been shown to
> reduce homocysteine dramatically.

Also thiamine (B1), niacin (B3) and inositol (B8), in addition
to folic acid (B9) and methylcobalamin (B12). Taking the
entire range of B-vitamins would probably be wisest.

Cheers, Michael C Price
----------------------------------------
http://mcp.longevity-report.com
http://www.hedweb.com/manworld.htm

[Tcomeau]

Matt <matt@downwithspammers-mengland.net> wrote in message
news:<kh7r10h2ou9lcte01l8mb3v3tgokcs3eh2@4ax.com>...
> Hello,
>
> My aunt has compiled the following "rules of thumb" that my
> family uses for our Alzheimer's prevention diet. Can anyone
> comment on these points and/or possibly point to other
> places of reference so that we can possibly learn more,
> maybe read about other perspectives/opinions on Alzheimer's
> prevention with diet? Are there other steps we might take
> above and beyond what is listed below?
>
> (My grandmother and great-grandmother have experienced
> Alzheimer's, so my family is quite sensitive and aware of
> any reasonable prevention measures that we can take.)
>
> -Matt
>
> [[ My aunt's compilation follows... ]]
>
> I've listed my prevention strategies in order of my
> perceived importance. These are not proven to inhibit the
> disease, but they are good health practices anyway?.so what
> do you have to lose?
>
> 1. Choline - This amino acid improves neuro-transmission
> in the memory portion of the brain. One of the reason
> that Grandma took the drug Aricept was to increase the
> choline production in the brain.
>
> Choline can be found in eggs, green leafy vegetables,
> legumes, and tofu. You can also by it in capsule form. There
> is no set daily dosage requirement.
>
> 2. Vitamin E - A powerful anti-oxidant believed to be the
> most important of all vitamins in preventing
> Alzheimer's. Most research supports taking well above
> the daily recommended dosage. I take 1,000
> mg. twice a day.
>
> 3. Vitamin C - Useful in the development of new brain
> cells which slows down at the onset of Alzheimer's.
> Again research suggests a higher than normal dosage. I
> take 1,000 mg. three times a day.
>
> 4. Fish oils - Omega 3 fatty acids are rich in fish oils.
> The highest dosage is found in sardines, salmon, tuna
> and turbot. You should be having a minimum of two
> servings per week. I take an fatty acid supplement
> three times a day that contains both Omega 3 and 6.
> Not only has it been found to improve brain
> efficiency, but it also maintains good joint health
> and helps guard cholesterol levels.
>
> 5. Homocysteine level in Blood - The higher the level of
> homocysteine, the more likely you are to develop the
> disease. Homocysteines has a toxic effect on brain
> cells that can begin to age the brain long before
> Alzheimer's sets in. A blood test can tell you if your
> levels are elevated. Take 2 mg. of folic acid to keep
> them under control. This is more than typically found
> in your daily multivitamin.
>
> 6. Aluminum - Avoid ingesting it. Aluminum shows up in
> the autopsies of Alzheimer's victims' brains. There
> toxic properties may contribute to the destruction of
> brain cells. Minimize your use of soda cans and
> aluminum cook ware. Watch for traces of harmful metals
> in your antacid and other over-the-counter drugs.
>
> 7. Ibuprofen - This in the most controversial of the
> recommendations I am making to you. This is because
> regular use of Important may lead to liver and kidney
> damage, as well as irritate your stomach lining.
> Nonetheless, inflammation is also believed to play a
> big factor in Alzheimer's. The swelling of the brain
> membranes is believed to play a part in the
> development of amyloid plaques in the brain.
>
> I take one 200 mg. tablet twice a day for several months,
> then alternate its use with an herbal supplement
> alternative. It is called Zyflamend from New Chapter. The
> herb is not only unproven, but more expensive than taking
> Advil. It is much fewer side effects, however.
>
> 8. Deep breathing - Oxygen to the brain is critically
> important to normal reticular activity that keeps your
> brain alert. Aerobic exercise, yoga or pilates are
> great ways to meet this need.
>
> 9. Water - Dehydration effects proper brain function, and
> most of us walk around in this condition every day
> without even realizing it. I keep a water bottle with
> me almost everywhere I go and drink one full bottle
> first thing every morning.
>
> Hope this helps. For more information you may log onto the
> Alzheimer's website at www.ALZ.org. The is some incredibly
> promising research out there using passive immunization of
> Beta Amyloids that are believed to be the primary cause of
> the disease. There are also a new advances in slowing down
> the disease through stimulation of nerve growth factors in
> the brain. Not much can be done at present until symptoms
> arise in the victim. Many researchers believe that the
> damage begins in the brain up to 20 years before these
> symptoms first occur. For this reason, it is none to soon
> for each of you to take a pro-active stance in your own
> personal prevention of the disease. I already give [my
> children that are 11 and 14] extra E and C and a choline
> supplement. They seldom drink soda or other canned drinks
> and I try to push the water as much as I can. I just can't
> see a down side to forming good habits now.

Don't forgrt to cut refined and High-GI load carbs:

http://www.sciencedaily.com/releases/1999/07/990728073646.htm

A Mayo Clinic study has shown that 50 percent of a group of
elderly patients with mild cognitive impairment who also have
a significantly smaller hippocampus portion of the brain are
likely to develop Alzheimer's disease as compared to nine
percent of patients with a normal size hippocampus

http://www.defeatdiabetes.org/Archives%20of%20News/march2003.-
htm

Sustained High Blood Sugar Levels May Damage Brain's Key
Memory Center
(03/10/03) An inability to quickly bring down high levels of
sugar in the blood is associated with poor memory
and may help explain some of the memory loss that
occurs as we age, according to a new study. The
Study raises the possibility that exercise and
weight loss, which help control blood sugar levels,
may be able to reverse some of the memory loss that
accompanies aging. The study is the first to show
an association between the size of the hippocampus,
a key brain structure for learning and memory, and
the ability to control blood sugar levels in the
body, according to the researchers.

http://diabetes.about.com/cs/hyperglycemia/a/blnmemory03.htm

"For every person with Alzheimer's disease, there are some 8
people with memory problems sufficient to affect the quality
of their lives who don't go on to develop dementia," says Dr.
Convit. "Our work seeks to understand what other medical
factors influence memory in aging." In fact, says Dr. Convit,
there are now more than 20 reports in the medical literature
demonstrating that diabetics experience memory and learning
problems that cannot be explained away by the presence of
other conditions such as cardiovascular disease, which are
often associated with diabetes. Diabetics have very high
levels of glucose in the blood because the sugar cannot enter
their tissues, where it is broken down to do useful work.

TC

[John 'The]

Once upon a time, our fellow Matt rambled on about
"Alzheimer's prevention diet: comment on this family's
strategies?." Our champion De-Medicalizing in
sci.med.nutrition retorts, thusly ...

>My aunt has compiled the following "rules of thumb" that my
>family uses for our Alzheimer's prevention diet.

Just about everything has been linked to causing Alzheimer's
Disease. There is no compiling proof that diet is the
primary factor.

In my opinion, the best prevention is using your brain, not
watching television all day, and getting plenty of exercise.
--
John Gohde, Achieving good Health is an Art, NOT a Science!

Health-with-Attitude is a weekly newsletter for people trying
to follow a Healthy Lifestyle.
http://groups.yahoo.com/group/Health-with-Attitude/

[Baird Staf]

Matt <matt@downwithspammers-mengland.net> wrote:

<snip>

> 2. Vitamin E - A powerful anti-oxidant believed to be the
> most important of all vitamins in preventing
> Alzheimer's. Most research supports taking well above
> the daily recommended dosage. I take 1,000
> mg. twice a day.

Be careful with the E! High doses of this vitamin act as an
effective blood-thinner, and should not be taken without
medical supervision if one is already taking a prescribed
blood thinner!

<snip>

> 6. Aluminum - Avoid ingesting it. Aluminum shows up in
> the autopsies of Alzheimer's victims' brains. There
> toxic properties may contribute to the destruction of
> brain cells. Minimize your use of soda cans and
> aluminum cook ware. Watch for traces of harmful metals
> in your antacid and other over-the-counter drugs.

I'm still waiting for a study on this one to indicate whether
the elevated levels of aluminum in the brains of Alzheimer's
victims are the cause of the disease or an effect of it.
However, since the chances in my estimation are fifty-fifty
either way, I choose to avoid it....

<snip>

Blessed be, Baird

[David Wrig]

In article <kh7r10h2ou9lcte01l8mb3v3tgokcs3eh2@4ax.com>, Matt
<matt@downwithspammers-mengland.net> wrote:

>6. Aluminum - Avoid ingesting it. Aluminum shows up in
> the autopsies of Alzheimer's victims' brains. There
> toxic properties may contribute to the destruction of
> brain cells. Minimize your use of soda cans and
> aluminum cook ware. Watch for traces of harmful metals
> in your antacid and other over-the-counter drugs.

Some antacids are aluminum compounds. However, the supposed
smoking gun for aluminum turned out to be shooting blanks --
the original "aluminum in the brains of Alzheimer's victims"
report was just bad lab work. They'd stained the brain tissue
samples with a stain that contained aluminum. Imagine that --
when the samples were analyzed, they contained aluminum!

There *may* be a connection between organic aluminum compounds
and Alzheimer's, but the evidence is very thin, and in any
case, those aren't compounds most people are coming into
contact with.

>9. Water - Dehydration effects proper brain function, and
> most of us walk around in this condition every day
> without even realizing it.

No, we don't. If we did, we would be thirsty. OK, I'll make an
exception for some older people, in whom the sense of thirst
may have become weaker, but the notion that "most of us" are
dehydrated is a medical urban legend.

-- David Wright :: alphabeta at prodigy.net These are my
opinions only, but they're almost always correct. "If I have
not seen as far as others, it is because giants were
standing on my shoulders." (Hal Abelson, MIT)

[David Wrig]

In article <1g8ja1e.19ehhxczmczycN%baird@newstaff.com>, Baird
Stafford <baird@newstaff.com> wrote:
>Matt <matt@downwithspammers-mengland.net> wrote:

>> 6. Aluminum - Avoid ingesting it. Aluminum shows up in
>> the autopsies of Alzheimer's victims' brains. There
>> toxic properties may contribute to the destruction of
>> brain cells. Minimize your use of soda cans and
>> aluminum cook ware. Watch for traces of harmful
>> metals in your antacid and other over-the-counter
>> drugs.
>
>I'm still waiting for a study on this one to indicate whether
>the elevated levels of aluminum in the brains of Alzheimer's
>victims are the cause of the disease or an effect of it.
>However, since the chances in my estimation are fifty-fifty
>either way, I choose to avoid it....

Also, the insides of aluminum cans are coated -- the beverage
doesn't actually come into contact with aluminum.

-- David Wright :: alphabeta at prodigy.net These are my
opinions only, but they're almost always correct. "If I have
not seen as far as others, it is because giants were
standing on my shoulders." (Hal Abelson, MIT)

[Michaelpri]

David Wright wrote
>>9. Water - Dehydration effects proper brain function, and
>> most of us walk around in this condition every day
>> without even realizing it.
>
> No, we don't. If we did, we would be thirsty. OK, I'll make
> an exception for some older people, in whom the sense of
> thirst may have become weaker, but the notion that "most of
> us" are dehydrated is a medical urban legend.

No, it has a basis in fact

Eur J Appl Physiol Occup Physiol 1988;57(2):220-4

Improved thermoregulation caused by forced water intake in
human desert dwellers.

Kristal-Boneh E, Glusman JG, Chaemovitz C, Cassuto Y.

Ben-Gurion University of the Negev, Beer Sheva, Israel.

Residents of the Negev desert in Israel sustain a mild state
of dehydration. Low, concentrated urine outputs, high
incidence of kidney diseases and high hematocrit ratios
characterize this population. Educational programs to increase
the awareness of the population to the dangers of dehydration
have undoubtedly failed. It was our purpose to see whether
forced increased drinking will affect the above variables. Ten
healthy subjects were asked to double their normal voluntary
water intake without (phase II) and with salt supplements (50
mM NaCl, 20 mM KCl) (phase III), for one week. After phases II
and III significant increases in body masses, decreased
concentrations of serum proteins, hemoglobin, hematocrit
ratios and serum osmolalities were found. No significant
changes were found in the concentrations of sodium and
potassium in the serum. At the end of each phase, the subjects
were asked to exercise on a bicycle ergometer for 60 min at
50% VO2max in a heated chamber at 45 degrees C, and 30%-50%
relative humidity. Experiments were terminated if and when
heart-rates exceeded 180 bpm or the rectal temperature
increased to 39 degrees C. After both experimental phases,
subjects increased their tolerance to heat, extending the
exercise periods by 25% and 30%. Compared with their starting
levels, hematocrit ratios, serum proteins and hemoglobin
concentrations increased in phases II and III while no changes
were recorded in the control period (phase I). It is suggested
that spontaneous voluntary water drinking in desert dwellers
is not enough to achieve a true state of "euhydration".

PMID: 3349990

Am Diet Assoc. 1999 Feb;99(2):200-6.

Erratum in: J Am Diet Assoc 1999 Apr;99(4):411.

Water: an essential but overlooked nutrient.

Kleiner SM.

Nutritional Sciences Program, University of Washington,
Seattle, USA.

Water is an essential nutrient required for life. To be well
hydrated, the average sedentary adult man must consume at
least 2,900 mL (12 c) fluid per day, and the average sedentary
adult woman at least 2,200 mL (9 c) fluid per day, in the form
of noncaffeinated, nonalcoholic beverages, soups, and foods.
Solid foods contribute approximately 1,000 mL (4 c) water,
with an additional 250 mL (1 c) coming from the water of
oxidation. The Nationwide Food Consumption Surveys indicate
that a portion of the population may be chronically mildly
dehydrated. Several factors may increase the likelihood of
chronic, mild dehydration, including a poor thirst mechanism,
dissatisfaction with the taste of water, common consumption of
the natural diuretics caffeine and alcohol, participation in
exercise, and environmental conditions. Dehydration of as
little as 2% loss of body weight results in impaired
physiological and performance responses. New research
indicates that fluid consumption in general and water
consumption in particular can have an effect on the risk of
urinary stone disease; cancers of the breast, colon, and
urinary tract; childhood and adolescent obesity; mitral valve
prolapse; salivary gland function; and overall health in the
elderly. Dietitians should be encouraged to promote and
monitor fluid and water intake among all of their clients and
patients through education and to help them design a fluid
intake plan. The influence of chronic mild dehydration on
health and disease merits further research.

Publication Types: Review Review, Academic

PMID: 9972188 Cheers, Michael C Price
----------------------------------------
http://mcp.longevity-report.com
http://www.hedweb.com/manworld.htm

[Tim Tyler]

In sci.life-extension David Wright <wright@clam.prodigy.net>
wrote or quoted:
> Matt <matt@downwithspammers-mengland.net> wrote:

> >9. Water - Dehydration effects proper brain function,
> > and most of us walk around in this condition every
> > day without even realizing it.
>
> No, we don't. If we did, we would be thirsty. OK, I'll make
> an exception for some older people, in whom the sense of
> thirst may have become weaker, but the notion that "most of
> us" are dehydrated is a medical urban legend.

...perpetuated by studies like this one:

``The Nationwide Food Consumption Surveys indicate that a
portion of the population may be chronically mildly
dehydrated. Several factors may increase the likelihood of
chronic, mild dehydration, including a poor thirst mechanism,
dissatisfaction with the taste of water, common consumption of
the natural diuretics caffeine and alcohol, participation in
exercise, and environmental conditions. Dehydration of as
little as 2% loss of body weight results in impaired
physiological and performance responses.''

- http://calorierestriction.org/pmid/?n=9972188
--
__________
|im |yler http://timtyler.org/ tim@tt1lock.org Remove
lock to reply.

[John 'The]

Once upon a time, our fellow Tim Tyler rambled on about "Re:
Alzheimer's prevention diet: comment on this family's
strategies?." Our champion De-Medicalizing in
sci.med.nutrition retorts, thusly ...

>> >9. Water - Dehydration effects proper brain function,
>> > and most of us walk around in this condition every
>> > day without even realizing it.
>>
>> No, we don't. If we did, we would be thirsty. OK, I'll make
>> an exception for some older people, in whom the sense of
>> thirst may have become weaker, but the notion that "most of
>> us" are dehydrated is a medical urban legend.
>
>...perpetuated by studies like this one:
>
> ``The Nationwide Food Consumption Surveys indicate that a
> portion of the
> population may be chronically mildly dehydrated. Several
> factors may

The water connection is an ancient concept developed by Dr.
Abram Hoffer with equally ancient research. :(

Actually, to be precise, forced water intake does not
cure Alzheimer's nor is it linked to it. It merely
removes a segment of the population misdiagnosed as
suffering from dementia.

Ergo, the problem is you science geeks misdiagnosing people
suffering from dehydration as having dementia.

Just thought that you might want to know. :)
--
John Gohde, Achieving good Health is an Art, NOT a Science!

Health-with-Attitude is a weekly newsletter for people trying
to follow a Healthy Lifestyle.
http://groups.yahoo.com/group/Health-with-Attitude/

[Tim Tyler]

John 'the Man' <DeMan@fdally.com> wrote or quoted:
> Once upon a time, our fellow Tim Tyler rambled on about
> [...]: Our champion De-Medicalizing in sci.med.nutrition
> retorts, thusly ...

> >> >9. Water - Dehydration effects proper brain
> >> > function, and most of us walk around in this
> >> > condition every day without even realizing it.
> >>
> >> No, we don't. If we did, we would be thirsty. OK, I'll
> >> make an exception for some older people, in whom the
> >> sense of thirst may have become weaker, but the notion
> >> that "most of us" are dehydrated is a medical urban
> >> legend.
> >
> >...perpetuated by studies like this one:
> >
> > ``The Nationwide Food Consumption Surveys indicate that a
> > portion of the
> > population may be chronically mildly dehydrated. Several
> > factors may
>
> The water connection is an ancient concept developed by Dr.
> Abram Hoffer with equally ancient research. :(
>
> Actually, to be precise, forced water intake does not cure
> Alzheimer's nor is it linked to it. It merely removes a
> segment of the population misdiagnosed as suffering from
> dementia.
>
> Ergo, the problem is you science geeks misdiagnosing people
> suffering from dehydration as having dementia.

FWIW, I never meant to make any claims about proper hydration
curing any degenerative disorders.

I do think that relatively few individuals are properly
hydrated much of the time, though.

Personally, I find it essential to carry a water bottle around
with me to stop me from entering what are plainly states of
mild dehydration.

I see a few others following this practice - but only a few.
--
__________
|im |yler http://timtyler.org/ tim@tt1lock.org Remove
lock to reply.

[Alf Christ]

On Mon, 2 Feb 2004 02:19:52 GMT, "John de Hoog"
<dehoog@dehoog.org> wrote:

>I'm surprised not to see B12 (as methylcobalamin, 500-1500
>micrograms per day) and betaine. B12 works well with folic
>acid to reduce homocysteine, and betaine has been shown to
>reduce homocysteine dramatically.

One problem with betaine is that it is quite osmotic active
and activated aldose reductase which produce sorbitol from
glucose in cells, which is also osmotic active and are very
little mobile over membranes since it is sterically hindered
to pass the Cl-regulated channel that do release taurine and
beta-alanine when cell is volume or osmotically challenged
(hypoosmosis), the increased sorbitol steady-state
concentration if rate of turnover is not increased in
parallell with synthesis will increase osmotic pressure inside
and thus force taurine and betaine to leave cell thus making
lack of protection against hyperhomocysteinamia and lack of
protection against uncontrolled glycation, eg. by lysine of
fructose to form an Amadori product 1-amino-1-deoxyfructose
lysine adduct) which most possibly taurine may prevent to be
formed by substituting lysine in the normal reaction since
normally, taurine will be in great excess as free amino acid
in cells (maybe one of the reasons intake of free amino acids
may be hazardous, while intake of taurine is not dangerous at
all since that will increase protection against formation of
such derangeous products as AGEs.

(There are several articles about taurine as glycation
scavenger), but here you should read Nature, vol 414, p.
413ff, Michael Brownlee, Biochemistry and molecular cell
biology of diabetic complications which doesn't mention one
word about taurine, but taurine is kicked out of cell by
mechanism 1 (several articles on cell volume regulation
taurine as search word, while it protects against glycation
products, it is involved in some phosporylations, and seem to
protect against PKC activation.

[John De Ho]

Alf Christophersen wrote...

> One problem with betaine is that it is quite osmotic active
> and activated aldose reductase which produce sorbitol from
> glucose in cells, which is also osmotic active and are very
> little mobile over membranes since it is sterically
> hindered to pass the Cl-regulated channel that do release
> taurine and beta-alanine when cell is volume or osmotically
> challenged (hypoosmosis), the increased sorbitol
> steady-state concentration if rate of turnover is not
> increased in parallell with synthesis will increase osmotic
> pressure inside and thus force taurine and betaine to leave
> cell thus making lack of protection against
> hyperhomocysteinamia and lack of protection against
> uncontrolled glycation, eg. by lysine of fructose to form
> an Amadori product 1-amino-1-deoxyfructose lysine adduct)
> which most possibly taurine may prevent to be formed by
> substituting lysine in the normal reaction since normally,
> taurine will be in great excess as free amino acid in cells
> (maybe one of the reasons intake of free amino acids may be
> hazardous, while intake of taurine is not dangerous at all
> since that will increase protection against formation of
> such derangeous products as AGEs.

Alf,

That was a bit difficult to follow, but what happens to people
(like us) who supplement 2 grams of taurine a day in addition
to a moderate amount of betaine?

--
John de Hoog http://dehoog.org

[John 'The]

Once upon a time, our fellow Tim Tyler rambled on about "Re:
Alzheimer's prevention diet: comment on this family's
strategies?." Our champion De-Medicalizing in
sci.med.nutrition retorts, thusly ...

>I do think that relatively few individuals are properly
>hydrated much of the time, though.
>
>Personally, I find it essential to carry a water bottle
>around with me to stop me from entering what are plainly
>states of mild dehydration.
>
>I see a few others following this practice - but only a few.

At least one study was published last year that said that was
just a bunch of hooey. :)

The elderly are chronically dehydrated in the extreme. That
does not mean that the average normal person needs to be
sipping at the water trough all day long.
--
John Gohde, Feeling Great and Better than Ever!

Healers who believe in the healing power of nature, Vis
Mediatix Naturae, worship Hygeia and the vital force.
http://tutorials.naturalhealthperspective.com/history.html

[David Wrig]

In article <ADJTb.47$gQ2.10@newsfep1-gui.server.ntli.net>,
michaelprice <michaelprice@ntlworld.com> wrote:
>David Wright wrote
>>>9. Water - Dehydration effects proper brain function, and
>>> most of us walk around in this condition every day
>>> without even realizing it.
>>
>> No, we don't. If we did, we would be thirsty. OK, I'll make
>> an exception for some older people, in whom the sense of
>> thirst may have become weaker, but the notion that "most of
>> us" are dehydrated is a medical urban legend.
>
>No, it has a basis in fact
>
> Eur J Appl Physiol Occup Physiol 1988;57(2):220-4
>
>Improved thermoregulation caused by forced water intake in
>human desert dwellers.

I don't know where you live, Michael, but I'm not a desert
dweller, and I assume that most of our readership would
say the same.

-- David Wright :: alphabeta at prodigy.net These are my
opinions only, but they're almost always correct. "If I have
not seen as far as others, it is because giants were
standing on my shoulders." (Hal Abelson, MIT)

[David Wrig]

In article <HsI6wL.Cwx@bath.ac.uk>, Tim Tyler
<tim@tt1lock.org> wrote:
>In sci.life-extension David Wright <wright@clam.prodigy.net>
>wrote or quoted:
>> Matt <matt@downwithspammers-mengland.net> wrote:
>
>> >9. Water - Dehydration effects proper brain function,
>> > and most of us walk around in this condition every
>> > day without even realizing it.
>>
>> No, we don't. If we did, we would be thirsty. OK, I'll make
>> an exception for some older people, in whom the sense of
>> thirst may have become weaker, but the notion that "most of
>> us" are dehydrated is a medical urban legend.
>
>...perpetuated by studies like this one:
>
>``The Nationwide Food Consumption Surveys indicate that a
>portion of the population may be chronically mildly
>dehydrated. Several factors may increase the likelihood of
>chronic, mild dehydration, including a poor thirst mechanism,
>dissatisfaction with the taste of water, common consumption
>of the natural diuretics caffeine and alcohol, participation
>in exercise, and environmental conditions. Dehydration of as
>little as 2% loss of body weight results in impaired
>physiological and performance responses.''

"A portion" of the population is remarkably vague. In fact,
it's so vague as to be useless.

-- David Wright :: alphabeta at prodigy.net These are my
opinions only, but they're almost always correct. "If I have
not seen as far as others, it is because giants were
standing on my shoulders." (Hal Abelson, MIT)

[David Wrig]

In article <7aYTb.258$gQ2.184@newsfep1-gui.server.ntli.net>,
michaelprice <michaelprice@ntlworld.com> wrote:
>David Wright <wright@clam.prodigy.net> wrote in message
>> In article <ADJTb.47$gQ2.10@newsfep1-gui.server.ntli.net>,
>> michaelprice <michaelprice@ntlworld.com> wrote:
>>>David Wright wrote
>>>>>9. Water - Dehydration effects proper brain function, and
>>>>> most of us walk around in this condition every day
>>>>> without even realizing it.
>>>>
>>>> No, we don't. If we did, we would be thirsty. OK, I'll
>>>> make an exception for some older people, in whom the
>>>> sense of thirst may have become weaker, but the notion
>>>> that "most of us" are dehydrated is a medical urban
>>>> legend.
>>>
>>> No, it has a basis in fact
>>>
>>> Eur J Appl Physiol Occup Physiol 1988;57(2):220-4
>>>
>>> Improved thermoregulation caused by forced water intake in
>>> human desert dwellers.
>>
>> I don't know where you live, Michael, but I'm not a desert
>> dweller, and I assume that most of our readership would say
>> the same.
>
>Irrelevant. Study shows that our thirst mechanism is not
>sufficient to drive optimal rehydration under some
>circumstances. This serves as a pointer or warning that we
>are probably dehydrated under less extreme circumstances.

No, at best it's a warning that we could be. If you're a
desert dweller, you're going to be far more aware of water,
and its scarcity, than will some city dweller who has an
unlimited supply from the nearest faucet. It's bound to
influence your behavior. I don't suffer from the symptoms
the article mentioned and I don't believe that most other
people do either. The whole "8 glasses of water per day"
thing is a myth.

-- David Wright :: alphabeta at prodigy.net These are my
opinions only, but they're almost always correct. "If I have
not seen as far as others, it is because giants were
standing on my shoulders." (Hal Abelson, MIT)

[Michaelpri]

David Wright <wright@clam.prodigy.net> wrote in message
> In article <ADJTb.47$gQ2.10@newsfep1-gui.server.ntli.net>,
> michaelprice <michaelprice@ntlworld.com> wrote:
>>David Wright wrote
>>>>9. Water - Dehydration effects proper brain function, and
>>>> most of us walk around in this condition every day
>>>> without even realizing it.
>>>
>>> No, we don't. If we did, we would be thirsty. OK, I'll
>>> make an exception for some older people, in whom the sense
>>> of thirst may have become weaker, but the notion that
>>> "most of us" are dehydrated is a medical urban legend.
>>
>> No, it has a basis in fact
>>
>> Eur J Appl Physiol Occup Physiol 1988;57(2):220-4
>>
>> Improved thermoregulation caused by forced water intake in
>> human desert dwellers.
>
> I don't know where you live, Michael, but I'm not a desert
> dweller, and I assume that most of our readership would say
> the same.

Irrelevant. Study shows that our thirst mechanism is not
sufficient to drive optimal rehydration under some
circumstances. This serves as a pointer or warning that we are
probably dehydrated under less extreme circumstances.

Cheers, Michael C Price
----------------------------------------
http://mcp.longevity-report.com
http://www.hedweb.com/manworld.htm

[Evelyn Ruu]

"David Wright" <wright@clam.prodigy.net> wrote in message
news:J5YTb.18710$cN7.11533@newssvr16.news.prodigy.com...
> In article <7aYTb.258$gQ2.184@newsfep1-gui.server.ntli.net>,
> michaelprice <michaelprice@ntlworld.com> wrote:
> >David Wright <wright@clam.prodigy.net> wrote in message
> >> In article
> >> <ADJTb.47$gQ2.10@newsfep1-gui.server.ntli.net>,
> >> michaelprice <michaelprice@ntlworld.com> wrote:
> >>>David Wright wrote
> >>>>>9. Water - Dehydration effects proper brain function,
> >>>>> and most of us walk around in this condition every
> >>>>> day without even realizing it.
> >>>>
> >>>> No, we don't. If we did, we would be thirsty. OK, I'll
> >>>> make an exception for some older people, in whom the
> >>>> sense of thirst may have become weaker, but the notion
> >>>> that "most of us" are dehydrated is a medical urban
> >>>> legend.
> >>>
> >>> No, it has a basis in fact
> >>>
> >>> Eur J Appl Physiol Occup Physiol 1988;57(2):220-4
> >>>
> >>> Improved thermoregulation caused by forced water intake
> >>> in human desert dwellers.
> >>
> >> I don't know where you live, Michael, but I'm not a
> >> desert dweller, and I assume that most of our readership
> >> would say the same.
> >
> >Irrelevant. Study shows that our thirst mechanism is not
> >sufficient to drive optimal rehydration under some
> >circumstances. This serves as a pointer or warning that we
> >are probably dehydrated under less extreme circumstances.
>
> No, at best it's a warning that we could be. If you're a
> desert dweller, you're going to be far more aware of water,
> and its scarcity, than will some city dweller who has an
> unlimited supply from the nearest faucet. It's bound to
> influence your behavior. I don't suffer from the symptoms
> the article mentioned and I don't believe that most other
> people do either. The whole "8 glasses of water per day"
> thing is a myth.

I might tend to agree with you about the 8 glasses, but I also
believe that most of us do not drink enough water. I know that
when I do remind myself to drink enough, I also have more
energy and generally feel better. Most people drink coffee,
tea, soda, but not in enough of a quantity to truly quench
thirst. Also many people interpret the feeling for thirst as
hunger and will eat instead of drink. Most treated (city)
water tastes disgusting and people will intuitively not drink
their fill. It is a good idea to remind oneself to drink more
water, though I would not go so far as to say that it causes
any kind of illness not to.
--
Evelyn

(To reply to me personally, remove sox)

[Eric Bohlm]

"michaelprice" <michaelprice@ntlworld.com> wrote in
news:7aYTb.258$gQ2.184@newsfep1-gui.server.ntli.net:

> Irrelevant. Study shows that our thirst mechanism is not
> sufficient to drive optimal rehydration under some
> circumstances. This serves as a pointer or warning that we
> are probably dehydrated under less extreme circumstances.

Those "some circumstances" are "circumstances in which one is
losing water rapidly," usually due to heavy sweating and less
frequently due to diarrhea. In those circumstances, relying
on thirst is a bad idea because the water loss is likely to
continue and any water consumed when thirst sets in won't be
absorbed instantaneously. But it's invalid to extrapolate
from circumstances involving heavy, prolonged water loss to
normal circumstances. Under normal circumstances, someone who
drinks when they're thirsty will restore their fluid balance
pretty quickly.

[Michaelpri]

"David Wright" <wright@clam.prodigy.net> wrote in message
news:J5YTb.18710$cN7.11533@newssvr16.news.prodigy.com...
> In article <7aYTb.258$gQ2.184@newsfep1-gui.server.ntli.net>,
> michaelprice <michaelprice@ntlworld.com> wrote:
> >David Wright <wright@clam.prodigy.net> wrote in message
> >> In article
> >> <ADJTb.47$gQ2.10@newsfep1-gui.server.ntli.net>,
> >> michaelprice <michaelprice@ntlworld.com> wrote:
> >>>David Wright wrote
> >>>>>9. Water - Dehydration effects proper brain function,
> >>>>> and most of us walk around in this condition every
> >>>>> day without even realizing it.
> >>>>
> >>>> No, we don't. If we did, we would be thirsty. OK, I'll
> >>>> make an exception for some older people, in whom the
> >>>> sense of thirst may have become weaker, but the notion
> >>>> that "most of us" are dehydrated is a medical urban
> >>>> legend.
> >>>
> >>> No, it has a basis in fact
> >>>
> >>> Eur J Appl Physiol Occup Physiol 1988;57(2):220-4
> >>>
> >>> Improved thermoregulation caused by forced water intake
> >>> in human desert dwellers.
> >>
> >> I don't know where you live, Michael, but I'm not a
> >> desert dweller, and I assume that most of our readership
> >> would say the same.
> >
> >Irrelevant. Study shows that our thirst mechanism is not
> >sufficient to drive optimal rehydration under some
> >circumstances. This serves as a pointer or warning that we
> >are probably dehydrated under less extreme circumstances.
>
> No, at best it's a warning that we could be. If you're a
> desert dweller, you're going to be far more aware of water,
> and its scarcity, than will some city dweller who has an
> unlimited supply from the nearest faucet.

The people in the study had free access to water. As they say
"It is suggested that spontaneous voluntary water drinking in
desert dwellers is not enough to achieve a true state of
"euhydration"."

Drinking water, in the past, was a health risk (parasites,
water-hole predation etc) which evolution traded off against
the benefits by duilling our thrist mechanism.

Cheers, Michael C Price
----------------------------------------
http://mcp.longevity-report.com
http://www.hedweb.com/manworld.htm

[Tim Tyler]

Eric Bohlman <ebohlman@earthlink.net> wrote or quoted:
> "michaelprice" <michaelprice@ntlworld.com> wrote:

> > Irrelevant. Study shows that our thirst mechanism is not
> > sufficient to drive optimal rehydration under some
> > circumstances. This serves as a pointer or warning that we
> > are probably dehydrated under less extreme circumstances.
>
> Those "some circumstances" are "circumstances in which one
> is losing water rapidly," usually due to heavy sweating and
> less frequently due to diarrhea. In those circumstances,
> relying on thirst is a bad idea because the water loss is
> likely to continue and any water consumed when thirst sets
> in won't be absorbed instantaneously. But it's invalid to
> extrapolate from circumstances involving heavy, prolonged
> water loss to normal circumstances. Under normal
> circumstances, someone who drinks when they're thirsty will
> restore their fluid balance pretty quickly.

When you are thirsty, you are already dehydrated ;-)
--
__________
|im |yler http://timtyler.org/ tim@tt1lock.org Remove
lock to reply.

[George W.]

"michaelprice" <michaelprice@ntlworld.com> wrote in message
news:064Ub.411$e83.121@newsfep1-gui.server.ntli.net...
> "David Wright" <wright@clam.prodigy.net> wrote in message
> news:J5YTb.18710$cN7.11533@newssvr16.news.prodigy.com...
> > In article
> > <7aYTb.258$gQ2.184@newsfep1-gui.server.ntli.net>,
> > michaelprice <michaelprice@ntlworld.com> wrote:
> > >David Wright <wright@clam.prodigy.net> wrote in message
> > >> In article
> > >> <ADJTb.47$gQ2.10@newsfep1-gui.server.ntli.net>,
> > >> michaelprice <michaelprice@ntlworld.com> wrote:
> > >>>David Wright wrote
> > >>>>>9. Water - Dehydration effects proper brain function,
> > >>>>> and most of us walk around in this condition every
> > >>>>> day without even realizing
it.
> > >>>>
> > >>>> No, we don't. If we did, we would be thirsty. OK,
> > >>>> I'll make an exception for some older people, in whom
> > >>>> the sense of thirst may have become weaker, but the
> > >>>> notion that "most of us" are dehydrated is a medical
> > >>>> urban legend.
> > >>>
> > >>> No, it has a basis in fact
> > >>>
> > >>> Eur J Appl Physiol Occup Physiol 1988;57(2):220-4
> > >>>
> > >>> Improved thermoregulation caused by forced water
> > >>> intake in human desert dwellers.
> > >>
> > >> I don't know where you live, Michael, but I'm not a
> > >> desert dweller, and I assume that most of our
> > >> readership would say the same.
> > >
> > >Irrelevant. Study shows that our thirst mechanism is not
> > >sufficient to drive optimal rehydration under some
> > >circumstances. This serves as a pointer or warning that
> > >we are probably dehydrated under less extreme
> > >circumstances.
> >
> > No, at best it's a warning that we could be. If you're a
> > desert dweller, you're going to be far more aware of
> > water, and its scarcity, than will some city dweller who
> > has an unlimited supply from the nearest faucet.
>
> The people in the study had free access to water. As they
> say "It is suggested that spontaneous voluntary water
> drinking in desert dwellers is not enough to achieve a true
> state of "euhydration"."
>
> Drinking water, in the past, was a health risk (parasites,
> water-hole predation etc) which evolution traded off against
> the benefits by duilling our thrist mechanism.

There's another problem in some older guys with benign
prostatic hyperplasia: they get tired of pee- ing every 15-30
minutes, and so they consciously restrict their water intake.

George W. Cherry

[John 'The]

Once upon a time, our fellow Tim Tyler rambled on about "Re:
Alzheimer's prevention diet: comment on this family's
strategies?." Our champion De-Medicalizing in
sci.med.nutrition retorts, thusly ...

>When you are thirsty, you are already dehydrated ;-)

Citations?
--
John Gohde, Feeling Great and Better than Ever!

Alternative medicine was yesterday's quackery, is today's
complementary medicine, and will be tomorrow's new branch of
medicine.
http://tutorials.naturalhealthperspective.com/glossary.html

[Tim Tyler]

John 'the Man' <DeMan@fdally.com> wrote or quoted:
> Once upon a time, our fellow Tim Tyler [wrote]:

> >When you are thirsty, you are already dehydrated ;-)
>
> Citations?

``Dehydration-induced drinking in humans

[...] Unlike some mammals, humans have a delay in
rehydration (involuntary dehydration) after fluid loss. Two
factors unique to humans that probably contribute to
involuntary dehydration are
1) upright posture and 2) extracellular fluid and
electrolyte loss by sweating from exercise and heat
exposure.''

- http://calorierestriction.org/pmid/?n=7044832
--
__________
|im |yler http://timtyler.org/ tim@tt1lock.org Remove
lock to reply.

[Drceephd]

baird@newstaff.com (Baird Stafford) wrote in message
news:<1g8ja1e.19ehhxczmczycN%baird@newstaff.com>...
> Matt <matt@downwithspammers-mengland.net> wrote:
>
> <snip>
>
> > 2. Vitamin E - A powerful anti-oxidant believed to be
> > the most important of all vitamins in preventing
> > Alzheimer's. Most research supports taking well
> > above the daily recommended dosage. I take 1,000
> > mg. twice a day.
>
> Be careful with the E! High doses of this vitamin act as an
> effective blood-thinner, and should not be taken without
> medical supervision if one is already taking a prescribed
> blood thinner!
>
> <snip>
>
> > 6. Aluminum - Avoid ingesting it. Aluminum shows up in
> > the autopsies of Alzheimer's victims' brains. There
> > toxic properties may contribute to the destruction
> > of brain cells. Minimize your use of soda cans and
> > aluminum cook ware. Watch for traces of harmful
> > metals in your antacid and other over-the-counter
> > drugs.
>
> I'm still waiting for a study on this one to indicate
> whether the elevated levels of aluminum in the brains of
> Alzheimer's victims are the cause of the disease or an
> effect of it. However, since the chances in my estimation
> are fifty-fifty either way, I choose to avoid it....
>
> <snip>
>
> Blessed be, Baird

In reading the posts in this thread I am surprised that no one
has commented on one very real way aluminum gets into our
bodies and, perhaps, our brains.

During the 60's, the elderly suffered from "senility" while we
were using phosphates in our detergents to wash our clothes.

Now we use zeolites to wash our clothes ( among many other
things ) and the elderly suffer from alzhiemers.

Zeolites ( molecular sieves ) are very small crystals capable
of ion exchange reactions which makes them useable for
detergents, and are also very thirsty molecules since they can
absorb water very well.

We substituted zeolites for phosphates in the 60s. Have we
exchanged alzheimers for senility in the process?

The problem is that zeolites are not water soluble nor
filterable by modern water processers. Thus, the chemicals are
in our water. Also, these chemicals are added to coffee
creamers ( look for sodium alumino silicate ) to salt and
other food stuffs to reduce caking since the FDA thinks that
they are safe to consume whithout telling you that you are
consuming them. However, in the human stomach, with its high
HCL content, these insoluble zeolites will be converted to
water soluble aluminum halides and possibly made blood soluble
and able to penetrate the blood brain barrier.

If this is true, you and I will have one hard time avoiding
the consequences of "Z E O L I T E " poisoning by consuming
much of what the modern food industry provides.

DrC PhD.

The doctor of the future will give no poisonous medicine in
the vain attempt to poison the sick into getting well.

The doctor of the future will interest the patient in the care
of the human frame, in diet, and in the cause and prevention
of disease, and a medical theory which will not include
bacteria, viruses, retro-viruses, or prions as the cause of
such diseases.

[Nightwing]

What is next weeks section of the periodic chart to be blamed?
Why not stick to alt.moron.idiot to post your rant of the day?

[Tim Tyler]

In sci.life-extension David Wright <wright@clam.prodigy.net>
wrote or quoted:
> In article <HsI6wL.Cwx@bath.ac.uk>, Tim Tyler
> <tim@tt1lock.org> wrote:
> >In sci.life-extension David Wright
> ><wright@clam.prodigy.net> wrote or quoted:
> >> Matt <matt@downwithspammers-mengland.net> wrote:
> >
> >> >9. Water - Dehydration effects proper brain
> >> > function, and most of us walk around in this
> >> > condition every day without even realizing it.
> >>
> >> No, we don't. If we did, we would be thirsty. OK, I'll
> >> make an exception for some older people, in whom the
> >> sense of thirst may have become weaker, but the notion
> >> that "most of us" are dehydrated is a medical urban
> >> legend.
> >
> >...perpetuated by studies like this one:
> >
> >``The Nationwide Food Consumption Surveys indicate that a
> >portion of the population may be chronically mildly
> >dehydrated. Several factors may increase the likelihood of
> >chronic, mild dehydration, including a poor thirst
> >mechanism, dissatisfaction with the taste of water, common
> >consumption of the natural diuretics caffeine and alcohol,
> >participation in exercise, and environmental conditions.
> >Dehydration of as little as 2% loss of body weight results
> >in impaired physiological and performance responses.''
>
> "A portion" of the population is remarkably vague. In fact,
> it's so vague as to be useless.

Slightly more specific:

``Relatively few studies have attempted to estimate people?s
actual water intakes. Stookey noted that the ?limited evidence
suggests that water intakes may vary considerably, and that a
sizeable proportion of Western adults may have sub-optimal
intakes? (ie chronically mildly dehydrated). [1]

A US nationwide dietary survey 1977-98 showed that the
median drinking water intake was less than one-third of the
recommended total amount.[2]

Stumbo et al [3] studied water intakes of lactating women
and found that one-third of their subjects had inadequate
water intake ? consuming less than 1ml water/kcal of energy
expenditure.

[...]

[1] Stookey JD. Another look at fuel + O2 ! CO2 + H2O.
Developing a water-orinted perspective. Medical
Hypotheses 1999;52:285-290

[2] United States Department of Agriculture, Consumer
Nutrition Division, Human Nutrition Information Service.
Nutrient Intakes: individuals in 48 states, Year 1977-78
(Nationwide Food Consumption Survey 1977-78, Report I-2)
Washington DC: US Government Printing Office, 1984,

[3] Stumbo PJ, Booth BM, Eichenberger JM, Dusdieker LB.
Water intakes of lactating women. Am J Clin Nutr
1985;42:870-876''

- http://www.rsph.org/water/water%20and%20health.pdf

[1] seems to be available:

``[...] Water intake and hydration status can vary
considerably, and may be inadequate for a sizeable proportion
of Western adults. Due to the metabolic adaptations required
to compensate for perpetually inadequate water, chronic
sub-optimal water intakes may be highly relevant to chronic
disease etiology. Preliminary evidence links water-oriented
metabolism to obesity, diabetes, cardiovascular disease,
hypertension and cancer. [...]''

- http://calorierestriction.org/pmid/?n=10465663
--
__________
|im |yler http://timtyler.org/ tim@tt1lock.org Remove
lock to reply.

[Ignoramus1]

In article <afd636a8.0402041856.126e9af7@posting.google.com>,
drceephd wrote:
> baird@newstaff.com (Baird Stafford) wrote in message
> news:<1g8ja1e.19ehhxczmczycN%baird@newstaff.com>...
>> Matt <matt@downwithspammers-mengland.net> wrote:
>>
>> <snip>
>>
>> > 2. Vitamin E - A powerful anti-oxidant believed to be
>> > the most important of all vitamins in preventing
>> > Alzheimer's. Most research supports taking well
>> > above the daily recommended dosage. I take 1,000
>> > mg. twice a day.
>>
>> Be careful with the E! High doses of this vitamin act as an
>> effective blood-thinner, and should not be taken without
>> medical supervision if one is already taking a prescribed
>> blood thinner!
>>
>> <snip>
>>
>> > 6. Aluminum - Avoid ingesting it. Aluminum shows up in
>> > the autopsies of Alzheimer's victims' brains. There
>> > toxic properties may contribute to the destruction
>> > of brain cells. Minimize your use of soda cans and
>> > aluminum cook ware. Watch for traces of harmful
>> > metals in your antacid and other over-the-counter
>> > drugs.
>>
>> I'm still waiting for a study on this one to indicate
>> whether the elevated levels of aluminum in the brains of
>> Alzheimer's victims are the cause of the disease or an
>> effect of it. However, since the chances in my estimation
>> are fifty-fifty either way, I choose to avoid it....
>>
>> <snip>
>>
>> Blessed be, Baird
>
> In reading the posts in this thread I am surprised that no
> one has commented on one very real way aluminum gets into
> our bodies and, perhaps, our brains.
>
> During the 60's, the elderly suffered from "senility" while
> we were using phosphates in our detergents to wash our
> clothes.
>
> Now we use zeolites to wash our clothes ( among many other
> things ) and the elderly suffer from alzhiemers.
>
> Zeolites ( molecular sieves ) are very small crystals
> capable of ion exchange reactions which makes them useable
> for detergents, and are also very thirsty molecules since
> they can absorb water very well.
>
> We substituted zeolites for phosphates in the 60s. Have we
> exchanged alzheimers for senility in the process?
>
> The problem is that zeolites are not water soluble nor
> filterable by modern water processers. Thus, the chemicals
> are in our water. Also, these chemicals are added to coffee
> creamers ( look for sodium alumino silicate ) to salt and
> other food stuffs to reduce caking since the FDA thinks that
> they are safe to consume whithout telling you that you are
> consuming them. However, in the human stomach, with its high
> HCL content, these insoluble zeolites will be converted to
> water soluble aluminum halides and possibly made blood
> soluble and able to penetrate the blood brain barrier.
>
> If this is true, you and I will have one hard time avoiding
> the consequences of "Z E O L I T E " poisoning by consuming
> much of what the modern food industry provides.
Presenting some actual evidence would be rather helpful!

i

[Tumbleweed]

"John 'the Man'" <DeMan@fDally.com> wrote in message
news:h47s10t9vsjmku06nlhhb9q02712jidaiv@4ax.com...
> Once upon a time, our fellow Matt rambled on about
> "Alzheimer's prevention diet: comment on this family's
> strategies?." Our champion De-Medicalizing in
> sci.med.nutrition retorts, thusly ...
>
> >My aunt has compiled the following "rules of thumb" that my
> >family uses for our Alzheimer's prevention diet.
>
> Just about everything has been linked to causing Alzheimer's
> Disease. There is no compiling proof that diet is the
> primary factor.
>
> In my opinion, the best prevention is using your brain, not
> watching television all day, and getting plenty of exercise.

Unfortunately there is plenty of evidence that doesnt work
either, for example my dad exervised regularily every day, and
the well known author Iris Murdoch who was certainly
intellectually active, died from Az.

--
Tumbleweed

Remove theobvious before replying (but no email reply
necessary to newsgroups)

[John 'The]

Once upon a time, our fellow Tumbleweed rambled on about "Re:
Alzheimer's prevention diet: comment on this family's
strategies?." Our champion De-Medicalizing in
sci.med.nutrition retorts, thusly ...

>my dad exervised regularily every day, and the well known
>author Iris Murdoch who was certainly intellectually active,
>died from Az.

Ever hear of the concept of genetics and how it relates to
your personal health?

Perhaps, you should educate yourself?
--
John Gohde, Achieving good Nutrition is an Art, NOT a Science!

Get started on improving your personal health and
fitness, today.
http://www.Tutorials.NaturalHealthPerspective.com/
Offering easy to understand lessons that will change
your life.

[Tumbleweed]

"michaelprice" <michaelprice@ntlworld.com> wrote in message
news:7aYTb.258$gQ2.184@newsfep1-gui.server.ntli.net...
> David Wright <wright@clam.prodigy.net> wrote in message
> > In article <ADJTb.47$gQ2.10@newsfep1-gui.server.ntli.net>,
> > michaelprice <michaelprice@ntlworld.com> wrote:
> >>David Wright wrote
> >>>>9. Water - Dehydration effects proper brain function,
> >>>> and most of us walk around in this condition every
> >>>> day without even realizing it.
> >>>
> >>> No, we don't. If we did, we would be thirsty. OK, I'll
> >>> make an exception for some older people, in whom the
> >>> sense of thirst may have become weaker, but the notion
> >>> that "most of us" are dehydrated is a medical urban
> >>> legend.
> >>
> >> No, it has a basis in fact
> >>
> >> Eur J Appl Physiol Occup Physiol 1988;57(2):220-4
> >>
> >> Improved thermoregulation caused by forced water intake
> >> in human desert dwellers.
> >
> > I don't know where you live, Michael, but I'm not a desert
> > dweller, and I assume that most of our readership would
> > say the same.
>
> Irrelevant. Study shows that our thirst mechanism is not
> sufficient to drive optimal rehydration under some
> circumstances. This serves as a pointer or warning that we
> are probably dehydrated under less extreme circumstances.
>

Not at all, the study shows that for this unusual population,
which consists of "concentrated urine outputs, high incidence
of kidney diseases and high hematocrit ratios". This is
obviously atypical. The study also says that increased
drinking improved thermoregulation, but this was again in an
envoronment (very high heat, very high exercise) that most of
us dont encounter in our daily lives. To the best of my
knowledge, its NEVER been 45 Deg C in the Uk for example, or
not since dinoasaurs roamed the planet. Maybe they could have
used this advice?

So the study doesn't serve as a pointer to anything.

--
Tumbleweed

Remove theobvious before replying (but no email reply
necessary to newsgroups)

[John 'The]

Once upon a time, our fellow Tumbleweed rambled on about "Re:
Alzheimer's prevention diet: comment on this family's
strategies?." Our champion De-Medicalizing in
sci.med.nutrition retorts, thusly ...

>the study shows that for this unusual population, ... This is
>obviously atypical. ... in an envoronment (very high heat,
>very high exercise) that most of us dont encounter in our
>daily lives.

Precisely!

You cannot make general health conclusions based upon kooky
populations studies.
--
John Gohde, Achieving good Health is an Art, NOT a Science!

Health-with-Attitude is a weekly newsletter for people trying
to follow a Healthy Lifestyle.
http://groups.yahoo.com/group/Health-with-Attitude/

[Eric Bohlm]

"Tumbleweed" <tumbleweednews@theobvioushotmail.com> wrote in
news:40239b07$0$15423$afc38c87@news.easynet.co.uk:

> "John 'the Man'" <DeMan@fDally.com> wrote in message
> news:h47s10t9vsjmku06nlhhb9q02712jidaiv@4ax.com...
>> In my opinion, the best prevention is using your brain, not
>> watching television all day, and getting plenty of
>> exercise.
>
> Unfortunately there is plenty of evidence that doesnt work
> either, for example my dad exervised regularily every day,
> and the well known author Iris Murdoch who was certainly
> intellectually active, died from Az.

You mean "doesn't *always* work"; it's entirely possible that
being mentally and physically active could substantially lower
the risk of develop Alzheimer's, just not by a factor of 100%.
Very little in life is black and white. There's no way to
absolutely *guarantee* that you won't develop a particular
illness (unless the illness is one specific to a body part
that was surgically removed; an appendectomy is an absolute
guarantee against future episodes of appendicitis).

"Prevention" doesn't mean "reducing risk to zero"; it means
"reducing risk as much as is practical." We've all heard of
people in good shape with healthy diets who die of heart
attacks at a young age, and we've all heard of out-of-shape
heavy smokers eating a fast-food diet until they die at the
age of 105. But that doesn't mean that more (not all) people
in good shape won't die of early heart attacks than those who
aren't, or that more (not all) people who avoid smoking,
exercise regularly, and eat well won't live past 100 than
those who don't.

[Evelyn Ruu]

One of the women in my alzheimer's support group for
caregivers, is presently caring for her husband who was a
brilliant physician. He studied actively and daily, was
physically active and ate a very good diet. He still got it.
--
Evelyn

(To reply to me personally, remove sox)

"Eric Bohlman" <ebohlman@earthlink.net> wrote in message
news:Xns94877A0883F13ebohlmanomsdevcom@130.133.1.17...
> "Tumbleweed" <tumbleweednews@theobvioushotmail.com> wrote in
> news:40239b07$0$15423$afc38c87@news.easynet.co.uk:
>
> > "John 'the Man'" <DeMan@fDally.com> wrote in message
> > news:h47s10t9vsjmku06nlhhb9q02712jidaiv@4ax.com...
> >> In my opinion, the best prevention is using your brain,
> >> not watching television all day, and getting plenty of
> >> exercise.
> >
> > Unfortunately there is plenty of evidence that doesnt work
> > either, for example my dad exervised regularily every day,
> > and the well known author Iris Murdoch who was certainly
> > intellectually active, died from Az.
>
> You mean "doesn't *always* work"; it's entirely possible
> that being mentally and physically active could
> substantially lower the risk of develop Alzheimer's, just
> not by a factor of 100%. Very little in life is black and
> white. There's no way to absolutely *guarantee* that you
> won't develop a particular illness (unless the illness is
> one specific to a body part that was surgically removed; an
> appendectomy is an absolute guarantee against future
> episodes of appendicitis).
>
> "Prevention" doesn't mean "reducing risk to zero"; it means
> "reducing risk as much as is practical." We've all heard of
> people in good shape with healthy diets who die of heart
> attacks at a young age, and we've all heard of out-of-shape
> heavy smokers eating a fast-food diet until they die at
the
> age of 105. But that doesn't mean that more (not all)
> people in good
shape
> won't die of early heart attacks than those who aren't,
> or that more (not all) people who avoid smoking, exercise
> regularly, and eat well won't live past 100 than those
> who don't.

[Tumbleweed]

"John 'the Man'" <DeMan@fmattly.com> wrote in message
news:a4s6201g2p4ejk4l54dmdjufav11nfv2ki@4ax.com...
> Once upon a time, our fellow Tumbleweed rambled on about
> "Re: Alzheimer's prevention diet: comment on this family's
> strategies?." Our champion De-Medicalizing in
> sci.med.nutrition retorts, thusly ...
>
> >my dad exervised regularily every day, and the well known
> >author Iris Murdoch who was certainly intellectually
> >active, died from Az.
>
> Ever hear of the concept of genetics and how it relates to
> your personal health?
>
> Perhaps, you should educate yourself?

Ever hear of the concept of good manners?

The simple fact is, that no simplistic or even complex set of
factors has been defintively identified as causitive for Az,
including diet, metal activity, and exercise.

> --
> John Gohde, Achieving good Nutrition is an Art, NOT a
> Science!

Nope, it should be a science, otherwise its just anectodal and
meaningless.

--
Tumbleweed

Remove theobvious before replying (but no email reply
necessary to newsgroups)

[Tumbleweed]

"Eric Bohlman" <ebohlman@earthlink.net> wrote in message
news:Xns94877A0883F13ebohlmanomsdevcom@130.133.1.17...
> "Tumbleweed" <tumbleweednews@theobvioushotmail.com> wrote in
> news:40239b07$0$15423$afc38c87@news.easynet.co.uk:
>
> > "John 'the Man'" <DeMan@fDally.com> wrote in message
> > news:h47s10t9vsjmku06nlhhb9q02712jidaiv@4ax.com...
> >> In my opinion, the best prevention is using your brain,
> >> not watching television all day, and getting plenty of
> >> exercise.
> >
> > Unfortunately there is plenty of evidence that doesnt work
> > either, for example my dad exervised regularily every day,
> > and the well known author Iris Murdoch who was certainly
> > intellectually active, died from Az.
>
> You mean "doesn't *always* work"; it's entirely possible
> that being mentally and physically active could
> substantially lower the risk of develop Alzheimer's, just
> not by a factor of 100%. Very little in life is black and
> white. There's no way to absolutely *guarantee* that you
> won't develop a particular illness (unless the illness is
> one specific to a body part that was surgically removed; an
> appendectomy is an absolute guarantee against future
> episodes of appendicitis).

Indeed, and when you can provide some proper scientific that
show that cause X or Y is the case,or has an association, I'll
be interested. To date, all the factors you mention and many
more have been anaylysed every which way with no conclusion.
Until then, dont waste your electrons.

>
> "Prevention" doesn't mean "reducing risk to zero"; it means
> "reducing risk as much as is practical." We've all heard of
> people in good shape with healthy diets who die of heart
> attacks at a young age, and we've all heard of out-of-shape
> heavy smokers eating a fast-food diet until they die at
the
> age of 105. But that doesn't mean that more (not all)
> people in good
shape
> won't die of early heart attacks than those who aren't,
> or that more (not all) people who avoid smoking, exercise
> regularly, and eat well won't live past 100 than those
> who don't.

This is all true but irrelevant when we are discussing a
disease that to date, apart from certain very specific genetic
factors, has not yet given up its causative factors to analyis
(apart from the loon who thinks its a virus that is treatable
by antibiotics :-)

--
Tumbleweed

Remove theobvious before replying (but no email reply
necessary to newsgroups)

[Tumbleweed]

"John 'the Man'" <DeMan@fmattly.com> wrote in message
news:i9s620lf07aoop50pemf0qhnooq4gbnp5l@4ax.com...
> Once upon a time, our fellow Tumbleweed rambled on about
> "Re: Alzheimer's prevention diet: comment on this family's
> strategies?." Our champion De-Medicalizing in
> sci.med.nutrition retorts, thusly ...
>
> >the study shows that for this unusual population, ... This
> >is obviously atypical. ... in an envoronment (very high
> >heat, very high exercise) that most of us dont encounter in
> >our daily lives.
>
> Precisely!
>
> You cannot make general health conclusions based upon kooky
> populations studies.

Doh!! That was the point, that whoever quoted this in support
of their theory was wasting their time.

--
Tumbleweed

Remove theobvious before replying (but no email reply
necessary to newsgroups)

[Chris]

"Tumbleweed" <tumbleweednews@theobvioushotmail.com> wrote in
message news:40239b07$0$15423$afc38c87@news.easynet.co.uk...
> Unfortunately there is plenty of evidence that doesnt work
> either, for example my dad exervised regularily every day,
> and the well known author Iris Murdoch who was certainly
> intellectually active, died from Az.

I've often heard that doing crossword puzzles helps to prevent
AD. I know someone who was and remains an avid
crossword-puzzle solver. She was diagnosed 2 years ago with
AD, yet remains an expert crossword puzzle solver.

--
Chris

[Jennie]

Matt,

The book "Aging with Grace - What the Nun Study Teaches Us
About Leading Longer, Healthier, and More Meaningful Lives",
by David Snowdon, PhD, has a chapter "Our Daily Bread" on this
topic. The major focus of this book is Alzheimers.

- Jennie

"Matt" <matt@downwithspammers-mengland.net> wrote in message
news:kh7r10h2ou9lcte01l8mb3v3tgokcs3eh2@4ax.com...
> Hello,
>
> My aunt has compiled the following "rules of thumb" that my
> family uses for our Alzheimer's prevention diet. Can anyone
> comment on these points and/or possibly point to other
> places of reference so that we can possibly learn more,
> maybe read about other perspectives/opinions on Alzheimer's
> prevention with diet? Are there other steps we might take
> above and beyond what is listed below?
>
> (My grandmother and great-grandmother have experienced
> Alzheimer's, so my family is quite sensitive and aware of
> any reasonable prevention measures that we can take.)
>
> -Matt
>
> [[ My aunt's compilation follows... ]]
>
> I've listed my prevention strategies in order of my
> perceived importance. These are not proven to inhibit the
> disease, but they are good health practices anyway..so what
> do you have to lose?
>
> 1. Choline - This amino acid improves neuro-transmission in
> the memory portion of the brain. One of the reason that
> Grandma took the drug Aricept was to increase the choline
> production in the brain.
>
> Choline can be found in eggs, green leafy vegetables,
> legumes, and tofu. You can also by it in capsule form. There
> is no set daily dosage requirement.
>
> 2. Vitamin E - A powerful anti-oxidant believed to be the
> most important of all vitamins in preventing Alzheimer's.
> Most research supports taking well above the daily
> recommended dosage. I take 1,000
> mg. twice a day.
>
> 3. Vitamin C - Useful in the development of new brain cells
> which slows down at the onset of Alzheimer's. Again
> research suggests a higher than normal dosage. I take
> 1,000 mg. three times a day.
>
> 4. Fish oils - Omega 3 fatty acids are rich in fish oils.
> The highest dosage is found in sardines, salmon, tuna and
> turbot. You should be having a minimum of two servings
> per week. I take an fatty acid supplement three times a
> day that contains both Omega 3 and 6. Not only has it
> been found to improve brain efficiency, but it also
> maintains good joint health and helps guard cholesterol
> levels.
>
> 5. Homocysteine level in Blood - The higher the level of
> homocysteine, the more likely you are to develop the
> disease. Homocysteines has a toxic effect on brain cells
> that can begin to age the brain long before Alzheimer's
> sets in. A blood test can tell you if your levels are
> elevated. Take 2 mg. of folic acid to keep them under
> control. This is more than typically found in your daily
> multivitamin.
>
> 6. Aluminum - Avoid ingesting it. Aluminum shows up in the
> autopsies of Alzheimer's victims' brains. There toxic
> properties may contribute to the destruction of brain
> cells. Minimize your use of soda cans and aluminum cook
> ware. Watch for traces of harmful metals in your antacid
> and other over-the-counter drugs.
>
> 7. Ibuprofen - This in the most controversial of the
> recommendations I am making to you. This is because
> regular use of Important may lead to liver and kidney
> damage, as well as irritate your stomach lining.
> Nonetheless, inflammation is also believed to play a big
> factor in Alzheimer's. The swelling of the brain
> membranes is believed to play a part in the development
> of amyloid plaques in the brain.
>
> I take one 200 mg. tablet twice a day for several months,
> then alternate its use with an herbal supplement
> alternative. It is called Zyflamend from New Chapter. The
> herb is not only unproven, but more expensive than taking
> Advil. It is much fewer side effects, however.
>
> 8. Deep breathing - Oxygen to the brain is critically
> important to normal reticular activity that keeps your
> brain alert. Aerobic exercise, yoga or pilates are great
> ways to meet this need.
>
> 9. Water - Dehydration effects proper brain function, and
> most of us walk around in this condition every day
> without even realizing it. I keep a water bottle with me
> almost everywhere I go and drink one full bottle first
> thing every morning.
>
> Hope this helps. For more information you may log onto the
> Alzheimer's website at www.ALZ.org. The is some incredibly
> promising research out there using passive immunization of
> Beta Amyloids that are believed to be the primary cause of
> the disease. There are also a new advances in slowing down
> the disease through stimulation of nerve growth factors in
> the brain. Not much can be done at present until symptoms
> arise in the victim. Many researchers believe that the
> damage begins in the brain up to 20 years before these
> symptoms first occur. For this reason, it is none to soon
> for each of you to take a pro-active stance in your own
> personal prevention of the disease. I already give [my
> children that are 11 and 14] extra E and C and a choline
> supplement. They seldom drink soda or other canned drinks
> and I try to push the water as much as I can. I just can't
> see a down side to forming good habits now.
> --
> Remove the obvious text (including the dash) to email me.

[Glenfiddic]

On Fri, 06 Feb 2004 23:10:02 GMT, "Chris"
<cnelsonpublic@hotmail.com> wrote:

>"Tumbleweed" <tumbleweednews@theobvioushotmail.com> wrote in
>message news:40239b07$0$15423$afc38c87@news.easynet.co.uk...
>> Unfortunately there is plenty of evidence that doesnt work
>> either, for example my dad exervised regularily every day,
>> and the well known author Iris Murdoch who was certainly
>> intellectually active, died from Az.

At the time my wife developed the first signs of AD, she was
managing our showbiz son; juggling school and auditions,
calling agents, picking up scripts - she kept mentally and
physically very busy. Of course, we didn't recognise those
signs until much later. . .

>I've often heard that doing crossword puzzles helps to
>prevent AD. I know someone who was and remains an avid
>crossword-puzzle solver. She was diagnosed 2 years ago with
>AD, yet remains an expert crossword puzzle solver.

That's possible if the crossword solving is a skill learned
early in life - AD tends to unwind the learned skill set from
the latest to the first.

Then there's another possiblity - that the answers she writes
in are no longer the correct ones!

[John 'The]

Once upon a time, our fellow Eric Bohlman rambled on about
"Re: Alzheimer's prevention diet: comment on this family's
strategies?." Our champion De-Medicalizing in
sci.med.nutrition retorts, thusly ...

>"Prevention" doesn't mean "reducing risk to zero"; it means
>"reducing risk as much as is practical."

Precisely! But, not exactly how I would put it.
--
John Gohde, Achieving good Nutrition is an Art, NOT a Science!

Get started on improving your personal health and
fitness, today.
http://www.Tutorials.NaturalHealthPerspective.com/
Offering easy to understand lessons that will change
your life.

[John 'The]

Once upon a time, our fellow Tumbleweed rambled on about "Re:
Alzheimer's prevention diet: comment on this family's
strategies?." Our champion De-Medicalizing in
sci.med.nutrition retorts, thusly ...

>The simple fact is, that no simplistic or even complex set of
>factors has been defintively identified as causitive for Az,
>including diet, metal activity, and exercise.

Precisely, what I stated in my first post.

And, once again, you are obviously totally ignorant on how to
apply genetics to the equation.

Educate yourself, and STOP being rude to me. :)
--
John Gohde, Achieving good Nutrition is an Art, NOT a Science!

Get started on improving your personal health and
fitness, today.
http://www.Tutorials.NaturalHealthPerspective.com/
Offering easy to understand lessons that will change
your life.

[John 'The]

Once upon a time, our fellow Tumbleweed rambled on about "Re:
Alzheimer's prevention diet: comment on this family's
strategies?." Our champion De-Medicalizing in
sci.med.nutrition retorts, thusly ...

>Until then, dont waste your electrons.

STOP being rude.

Did you read how Alzheimer's suffers are often victims of
violence in nursing homes?

Something you need to educate yourself on, Dim-Wit! Otherwise,
your fellow Dim-Wits will only beat the crap out of you. Ha,
... Hah, Ha!

Just my opinion. But, I am *right* as usual!

[Alf Christ]

On Tue, 03 Feb 2004 21:26:24 GMT, "John de Hoog"
<dehoog@dehoog.org> wrote:

>That was a bit difficult to follow, but what happens to
>people (like us) who supplement 2 grams of taurine a day in
>addition to a moderate amount of betaine?

Depends most possibly on how much of htat is excreted daily in
urine and faeces as gall salts.

But most probably you may have a better defence against AGE
formation, but that's dependent on theories where the first
step in AGE formation is forming a glucosederived lysine
adduct. When taurine is in excess compared to lysine, most
possible the taurine analogue are formed and then it is
interesting to know what happens with a glucose taurine
adduct. (The amadori-product of 1-deoxyfructose and taurine
which I think has not been analyzed yet.(see also Nature vol
414 13. december 2001, p. 814 where 1-deoxyfructose-lysine
amadori product is mentioned as an earlt step in AGE
formation)

[Mike Leake]

"John de Hoog" <dehoog@dehoog.org> wrote in message
news:4mUTb.7487732$Of.1207446@news.easynews.com...
> Alf Christophersen wrote...
>
> > One problem with betaine is that it is quite osmotic
> > active and activated aldose reductase which produce
> > sorbitol from glucose in cells, which is also osmotic
> > active and are very little mobile over membranes since it
> > is sterically hindered to pass the Cl-regulated channel
> > that do release taurine and beta-alanine when cell is
> > volume or osmotically challenged (hypoosmosis), the
> > increased sorbitol steady-state concentration if rate of
> > turnover is not increased in parallell with synthesis will
> > increase osmotic pressure inside and thus force taurine
> > and betaine to leave cell thus making lack of protection
> > against hyperhomocysteinamia and lack of protection
> > against uncontrolled glycation, eg. by lysine of fructose
> > to form an Amadori product 1-amino-1-deoxyfructose lysine
> > adduct) which most possibly taurine may prevent to be
> > formed by substituting lysine in the normal reaction since
> > normally, taurine will be in great excess as free amino
> > acid in cells (maybe one of the reasons intake of free
> > amino acids may be hazardous, while intake of taurine is
> > not dangerous at all since that will increase protection
> > against formation of such derangeous products as AGEs.
>
> Alf,
>
> That was a bit difficult to follow
<snip> One sentence paragraphs generally are difficult to
follow, especially when they're of a technical nature. I gave
up after the third reading. :-)

[Daphne]

Tumbleweed,

After reading through a ton of messages and getting more
overhelmed by the minute, your post made me smile. Not sure
why but it was something to do with calling someone a 'loon'.

Thanks for the smile. I needed that.

Daphne

"Tumbleweed" <tumbleweednews@theobvioushotmail.com> wrote in
message news:<4024148c$0$15418$afc38c87@news.easynet.co.uk>...

> This is all true but irrelevant when we are discussing a
> disease that to date, apart from certain very specific
> genetic factors, has not yet given up its causative factors
> to analyis (apart from the loon who thinks its a virus that
> is treatable by antibiotics :-)

[Mark]

Alf Christophersen <alf.christophersen@basalmed.uio.no> wrote
in message
news:<ebuv10lah38du7g23kisuciid7k6al515p@4ax.com>...
> On Mon, 2 Feb 2004 02:19:52 GMT, "John de Hoog"
> <dehoog@dehoog.org> wrote:
>
> One problem with betaine is that it is quite osmotic active
> and activated aldose reductase which produce sorbitol from
> glucose in cells, which is also osmotic active and are very
> little mobile over membranes since it is sterically
> hindered to pass the Cl-regulated channel that do release
> taurine and beta-alanine when cell is volume or osmotically
> challenged (hypoosmosis), the increased sorbitol
> steady-state concentration if rate of turnover is not
> increased in parallell with synthesis will increase osmotic
> pressure inside and thus force taurine and betaine to leave
> cell thus making lack of protection against
> hyperhomocysteinamia and lack of protection against
> uncontrolled glycation, eg. by lysine of fructose to form
> an Amadori product 1-amino-1-deoxyfructose lysine adduct)
> which most possibly taurine may prevent to be formed by
> substituting lysine in the normal reaction since normally,
> taurine will be in great excess as free amino acid in cells
> (maybe one of the reasons intake of free amino acids may be
> hazardous, while intake of taurine is not dangerous at all
> since that will increase protection against formation of
> such derangeous products as AGEs.
>
> (There are several articles about taurine as glycation
> scavenger), but here you should read Nature, vol 414, p.
> 413ff, Michael Brownlee, Biochemistry and molecular cell
> biology of diabetic complications which doesn't mention one
> word about taurine, but taurine is kicked out of cell by
> mechanism 1 (several articles on cell volume regulation
> taurine as search word, while it protects against glycation
> products, it is involved in some phosporylations, and seem
> to protect against PKC activation.

Thank you for this very informative post. It is obvious that
TMG has a dark side too, which I have not heard before. At
least no supplement vendor I know ever mentions it. I think
the implication is that anhydrous betaine (TMG) may cause
cataracts at least in diabetics. see the links below.
Interestingly, one web site
(http://www.wizardofeyez.com/cataract_nutrition.html)
recommends quercetin which is an aldose reductase inhibitor to
prevent cataracts, but also recommends lysine and TMG. (it
mentions only one water soluble form, quercetin dehydrate, but
there are others e.g. Quercetin Chalcone)

http://www.findarticles.com/cf_dls/m0FDN/2_6/74510830/p9/arti-
cle.jhtml?term=

A group of researchers examined the effect of an orally
administered ARI in inhibiting polyol accumulation. They
reported the arrest of cataracts in galactosemic rats by oral
feeding of a synthetic ARI.[57] Building on this research,
another group studied the effect of a flavonoid ARI,
quercetrin (a glycoside of quercetin). Rats were divided into
two groups, one receiving lab chow only, while the
experimental group was fed quercetrin in rat chow plus an
additional 70 mg oral quercetrin daily in aqueous suspension.
Three days after beginning flavonoid supplementation diabetes
was chemically induced and three days later lenses were
assessed for sorbitol and fructose. The flavonoid group
demonstrated a 50-percent inhibition of sorbitol and fructose
accumulation. The control group developed cataracts by the
tenth day, whereas the group receiving quercetrin, although
their blood sugar was comparable (average 380 mg/100 mL), had
not developed cataracts by the 25th day.[58] A French study
examining the effect of oral doses of quercetin did not find
an inhibition of cataract formation in diabetic animals.[59]
In the positive study quercetrin rather than quercetin was
used, the former administered in a water suspension which was
undoubtedly more absorbable. The latter study was in French
with only the abstract available so a dosage comparison was
not possible

http://www.essex.ac.uk/bs/staff/thornalley/polyol.htm

http://www.tellpharm.com/products/CACHEXON/New_Uses/eyediseas-
e/cataract99-00.htm Dietary taurine supplementation cannot be
regarded as an alternative to aldose reductase inhibition in
eliminating antioxidant and metabolic deficits contributing to
diabetes-associated cataractogenesis.

[No Crosspo]

Would you idiots STOP CROSSPOSTING THIS CRAP TO
ALT.SUPPORT.ALZHEIMERS, THANK YOU? Please practice good
netiquette and stop all these non-caregiver threads on our
newsgroup.

(followups trimmed)

On 9 Feb 2004 15:55:03 -0800 in alt.support.alzheimers,
mzbresson@yahoo.com (mark) wrote:

> Alf Christophersen <alf.christophersen@basalmed.uio.no>
> wrote in message
> news:<ebuv10lah38du7g23kisuciid7k6al515p@4ax.com>...
> > On Mon, 2 Feb 2004 02:19:52 GMT, "John de Hoog"
> > <dehoog@dehoog.org> wrote:
> >
> > One problem with betaine

[Kim Marlow]

I find your post intresting, because it opens a rather large
list of possibilities of what is really going on inside the
cell. If quercetrin truely reduces the rate of cataracts in
lab animals then it could be working not as a inhibitor, but
as a E1, E2, or E3 protease to help break down sorbitol and
fruittose accumulation by combining with ubiquitin or one of
the other ubiquitin like proteins to mark these for
destruction. I wonder if a increase in avalible Mn, or Co
(B12) would inprove the over all effect of quercetrin.

[taurusrc]

Better yet, why don't you learn how to use your DELETE key.

Ora

On Mon, 09 Feb 2004 22:56:09 -0900,
no.crossposts@here.com wrote:

>Would you idiots STOP CROSSPOSTING THIS CRAP TO
>ALT.SUPPORT.ALZHEIMERS, THANK YOU? Please practice good
>netiquette and stop all these non-caregiver threads on our
>newsgroup.
>
>(followups trimmed)
>
>On 9 Feb 2004 15:55:03 -0800 in alt.support.alzheimers,
>mzbresson@yahoo.com (mark) wrote:
>
>> Alf Christophersen <alf.christophersen@basalmed.uio.no>
>> wrote in message
>> news:<ebuv10lah38du7g23kisuciid7k6al515p@4ax.com>...
>> > On Mon, 2 Feb 2004 02:19:52 GMT, "John de Hoog"
>> > <dehoog@dehoog.org> wrote:
>> >
>> > One problem with betaine

[Kim Marlow]

This is a multi-part message in MIME format.

------=_NextPart_000_003B_01C3F1BA.416428C0 Content-Type:
text/plain; charset="iso-8859-1" Content-Transfer-Encoding:
quoted-printable

Lady I made 1 post to the "Misc.health alternative" If you
have problem = with cross posters I suggest you take it up
with your group administate. = Hopping over here and being
rude won't help the issue. Good luck with = your problems.
<taurusrc@aol.com> wrote in message =
news:oikj209r95so9dhqcgravfolavdvb494v2@4ax.com...
> Better yet, why don't you learn how to use your DELETE
> key. =20
>=20
> Ora
>=20 20
> On Mon, 09 Feb 2004 22:56:09 -0900,
> no.crossposts@here.com wrote:
>=20
> >Would you idiots STOP CROSSPOSTING THIS CRAP TO
> >ALT.SUPPORT.ALZHEIMERS, THANK YOU? Please practice good
> >netiquette and stop all these non-caregiver threads on our
> >newsgroup.
> >
> >(followups trimmed)
> >
> >On 9 Feb 2004 15:55:03 -0800 in alt.support.alzheimers,
> >mzbresson@yahoo.com (mark) wrote:
> >
> >> Alf Christophersen <alf.christophersen@basalmed.uio.no>
> >> wrote in =
message news:<ebuv10lah38du7g23kisuciid7k6al515p@4ax.com>...
> >> > On Mon, 2 Feb 2004 02:19:52 GMT, "John de Hoog" =
<dehoog@dehoog.org>
> >> > wrote:
> >> >=20
> >> > One problem with betaine
>=20

------=_NextPart_000_003B_01C3F1BA.416428C0 Content-Type:
text/html; charset="iso-8859-1" Content-Transfer-Encoding:
quoted-printable

<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.0 Transitional//EN">
<HTML><HEAD> <META http-equiv=3DContent-Type
content=3D"text/html; = charset=3Diso-8859-1"> <META
content=3D"MSHTML 6.00.2600.0" name=3DGENERATOR>
<STYLE></STYLE> </HEAD> <BODY>
<DIV><FONT size=3D2></FONT><STRONG><FONT face=3DArial>Lady I
made 1 post = to the=20 "Misc.health alternative" If you
have problem with cross posters I = suggest you=20 take
it up with your group administate. Hopping over here and
being rude = won't=20 help the issue. Good luck with your
problems.</FONT></STRONG></DIV>
<DV><FONT face=3DArial size=3D2>&lt;</FONT><A =
href=3D"mailto:taurusrc@aol.com"><FONT=20 face=3DArial
size=3D2>taurusrc@aol.com</FONT></A><FONT face=3DArial =
size=3D2>&gt; wrote=20 in message </FONT><A=20 href=3D"n-
ews:oikj209r95so9dhqcgravfolavdvb494v2@4ax.com"><FONT =
face=3DArial=20 size=3D2>news:oikj209r95so9dhqcgravfolav-
dvb494v2@4ax.com</FONT></A><FONT =

face=3DArial size=3D2>...</FONT></DIV><FONT face=3DArial
size=3D2>&gt; = Better yet, why=20 don't you learn how to use
your DELETE key.&nbsp; <BR>&gt; <BR>&gt; = Ora<BR>&gt;=20
<BR>&gt; <BR>&gt; On Mon, 09 Feb 2004 22:56:09 -0900,
</FONT><A=20 href=3D"mailto:no.crossposts@here.com"><FONT
face=3DArial=20
size=3D2>no.crossposts@here.com</FONT></A><FONT face=3DArial
size=3D2> = wrote:<BR>&gt;=20 <BR>&gt; &gt;Would you idiots
STOP CROSSPOSTING THIS CRAP TO<BR>&gt;=20
&gt;ALT.SUPPORT.ALZHEIMERS, THANK YOU?&nbsp; Please practice =
good<BR>&gt;=20 &gt;netiquette and stop all these
non-caregiver threads on our<BR>&gt;=20 &gt;newsgroup.<BR>&gt;
&gt;<BR>&gt; &gt;(followups trimmed)<BR>&gt; = &gt;<BR>&gt;=20
&gt;On 9 Feb 2004 15:55:03 -0800 in
alt.support.alzheimers,<BR>&gt;=20 &gt;mzbresson@yahoo.com
(mark) wrote:<BR>&gt; &gt;<BR>&gt; &gt;&gt; Alf=20
Christophersen &lt;</FONT><A=20
href=3D"mailto:alf.christophersen@basalmed.uio.no"><FONT
face=3DArial=20
size=3D2>alf.christophersen@basalmed.uio.no</FONT></A><FONT
face=3DArial = size=3D2>&gt;=20 wrote in message </FONT><A=20
href=3D"news:<ebuv10lah38du7g23kisuciid7k6al515p@4ax.com"><FO-
NT = face=3DArial=20 size=3D2>news:&lt;ebuv10lah38du7g23kisuc-
iid7k6al515p@4ax.com</FONT></A><F= ONT=20 face=3DArial
size=3D2>&gt;...<BR>&gt; &gt;&gt; &gt; On Mon, 2 Feb 2004 =
02:19:52 GMT,=20 "John de Hoog" &lt;</FONT><A
href=3D"mailto:dehoog@dehoog.org"><FONT =
face=3DArial=20
size=3D2>dehoog@dehoog.org</FONT></A><FONT face=3DArial
= size=3D2>&gt;<BR>&gt; &gt;&gt;=20 &gt; wrote:<BR>&gt;
&gt;&gt; &gt; <BR>&gt; &gt;&gt; &gt; One problem =
with=20 betaine<BR>&gt; </FONT></BODY></HTML>

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[Alf Christ]

On Mon, 02 Feb 2004 01:05:49 GMT, Matt
<matt@downwithspammers-mengland.net> wrote:

>4. Fish oils - Omega 3 fatty acids are rich in fish oils.
> The highest dosage is found in sardines, salmon, tuna
> and turbot. You should be having a minimum of two
> servings per week. I take an fatty acid supplement
> three times a day that contains both Omega 3 and 6.
> Not only has it been found to improve brain
> efficiency, but it also maintains good joint health
> and helps guard cholesterol levels.

Be sure the ratio omega-6 : omega-3 don't get above 10, 2-5 is
probably best, but the MUFA:PUFA ratio should be high.

Read about levuglandin and isolevuglandins at Pubmed,
especially levuglandin and alzheimer. Levuglandin is a
ketoaldehyde product of PGH, either formed spontaneous, but
could also be made from attack by myeloperoxidases in
activated macrophage.

it is reasonable that taurine and other amines not being
lysine would protect proteins being attacked at the lysine
side groups in proteins, a reaction which takes only a few
seconds to occure after formation of levuglandin.

Levuglandin:
1. Boutaud O, Li J, Zagol I, Shipp EA, Davies SS, Roberts LJ
2nd, Oates JA. Links Levuglandinyl adducts of proteins are
formed via a prostaglandin H2 synthase-dependent pathway
after platelet activation. J Biol Chem. 2003 May
9;278(19):16926-8. Epub 2003 Mar 11. PMID: 12637576
[PubMed - indexed for MEDLINE]

2: Boutaud O, Ou JJ, Chaurand P, Caprioli RM, Montine TJ,
Oates JA. Links Prostaglandin H2 (PGH2) accelerates
formation of amyloid beta1-42 oligomers. J Neurochem.
2002 Aug;82(4):1003-6. PMID: 12358806 [PubMed - indexed
for MEDLINE]

3: Boutaud O, Li J, Chaurand P, Brame CJ, Marnett LJ,
Roberts LJ, Oates JA. Links Oxygenation of arachidonic
acid by cyclooxygenases generates reactive intermediates
that form adducts with proteins. Adv Exp Med Biol.
2001;500:133-7. No abstract available. PMID: 11764925
[PubMed - indexed for MEDLINE]

4: Boutaud O, Brame CJ, Chaurand P, Li J, Rowlinson SW,
Crews BC, Ji C, Marnett LJ, Caprioli RM, Roberts LJ
2nd, Oates JA. Links Characterization of the lysyl
adducts of prostaglandin H-synthases that are derived
from oxygenation of arachidonic acid. Biochemistry.
2001 Jun 12;40(23):6948-55. PMID: 11389610 [PubMed -
indexed for MEDLINE]

5: Salomon RG, Batyreva E, Kaur K, Sprecher DL, Schreiber
MJ, Crabb JW, Penn MS, DiCorletoe AM, Hazen SL, Podrez
EA. Links Isolevuglandin-protein adducts in humans:
products of free radical-induced lipid oxidation through
the isoprostane pathway. Biochim Biophys Acta. 2000 May
31;1485(2-3):225-35. PMID: 10832102 [PubMed - indexed
for MEDLINE]

6: Boutaud O, Brame CJ, Salomon RG, Roberts LJ 2nd, Oates
JA. Links Characterization of the lysyl adducts formed
from prostaglandin H2 via the levuglandin pathway.
Biochemistry. 1999 Jul 20;38(29):9389-96. PMID: 10413514
[PubMed - indexed for MEDLINE]

7: Salomon RG, Sha W, Brame C, Kaur K, Subbanagounder G,
O'Neil J, Hoff HF, Roberts LJ 2nd. Links Protein adducts
of iso[4]levuglandin E2, a product of the isoprostane
pathway, in oxidized low density lipoprotein. J Biol
Chem. 1999 Jul 16;274(29):20271-80. PMID: 10400646
[PubMed - indexed for MEDLINE]

8: Brame CJ, Salomon RG, Morrow JD, Roberts LJ 2nd. Links
Identification of extremely reactive gamma-ketoaldehydes
(isolevuglandins) as products of the isoprostane pathway
and characterization of their lysyl protein adducts. J
Biol Chem. 1999 May 7;274(19):13139-46. PMID: 10224068
[PubMed - indexed for MEDLINE]

9: Salomon RG, Subbanagounder G, Singh U, O'Neil J, Hoff
HF. Links Oxidation of low-density lipoproteins
produces levuglandin-protein adducts. Chem Res Toxicol.
1997 Jul;10(7):750-9. PMID: 9250408 [PubMed - indexed
for MEDLINE]

10: Salomon RG, Subbanagounder G, O'Neil J, Kaur K, Smith MA,
Hoff HF, Perry G, Monnier VM. Links Levuglandin
E2-protein adducts in human plasma and vasculature. Chem
Res Toxicol. 1997 May;10(5):536-45. PMID: 9168251 [PubMed
- indexed for MEDLINE]

11: Hoppe G, Subbanagounder G, O'Neil J, Salomon RG, Hoff HF.
Links Macrophage recognition of LDL modified by
levuglandin E2, an oxidation product of arachidonic acid.
Biochim Biophys Acta. 1997 Jan 7;1344(1):1-5. PMID:
9022751 [PubMed - indexed for MEDLINE]

12: DiFranco E, Subbanagounder G, Kim S, Murthi K, Taneda S,
Monnier VM, Salomon RG. Links Formation and stability of
pyrrole adducts in the reaction of levuglandin E2 with
proteins. Chem Res Toxicol. 1995 Jan-Feb;8(1):61-7. PMID:
7703368 [PubMed - indexed for MEDLINE]

13: Murthi KK, Friedman LR, Oleinick NL, Salomon RG.
Links Formation of DNA-protein cross-links in
mammalian cells by levuglandin E2. Biochemistry. 1993
Apr 20;32(15):4090-7. PMID: 8471616 [PubMed - indexed
for MEDLINE]

14: Schmidley JW, Dadson J, Iyer RS, Salomon RG. Links Brain
tissue injury and blood-brain barrier opening induced by
injection of LGE2 or PGE2. Prostaglandins Leukot Essent
Fatty Acids. 1992 Oct;47(2):105-10. PMID: 1461920 [PubMed
- indexed for MEDLINE]

15: Foreman D, Solomon RG. Links Evidence that the
prostaglandin E2 receptor and the anhydrolevuglandin E2
receptor in the rat uterus are the same receptor.
Prostaglandins. 1992 Mar;43(3):263-70. PMID: 1321465
[PubMed - indexed for MEDLINE]

16: Jirousek MR, Murthi KK, Salomon RG. Links
Electrophilic levuglandin E2-protein adducts bind
glycine: a model for protein crosslinking.
Prostaglandins. 1990 Aug;40(2):187-203. PMID: 2217833
[PubMed - indexed for MEDLINE]

17: Murthi KK, Salomon RG, Sternlicht H. Links Levuglandin E2
inhibits mitosis and microtubule assembly.
Prostaglandins. 1990 Jun;39(6):611-22. PMID: 2115185
[PubMed - indexed for MEDLINE]

18: Iyer RS, Ghosh S, Salomon RG. Links Levuglandin E2
crosslinks proteins. Prostaglandins. 1989
Apr;37(4):471-80. PMID: 2762557 [PubMed - indexed
for MEDLINE]

19: Salomon RG, Jirousek MR, Ghosh S, Sharma RB. Links
Prostaglandin endoperoxides 21. Covalent binding of
levuglandin E2 with proteins. Prostaglandins. 1987
Nov;34(5):643-56. PMID: 3481092 [PubMed - indexed
for MEDLINE]

20: Foreman D, Zuk L, Miller DB, Salomon RG. Links Effects of
E2 levuglandins on the contractile activity of the rat
uterus. Prostaglandins. 1987 Jul;34(1):91-8. PMID:
3317517 [PubMed - indexed for MEDLINE]

Salomon RG, Miller DB. Related Articles, Links
Levuglandins: isolation, characterization, and total
synthesis of new secoprostanoid products from prostaglandin
endoperoxides. Adv Prostaglandin Thromboxane Leukot Res.
1985;15:323-6. No abstract available. PMID: 2936114 [PubMed
- indexed for MEDLINE]

Isolevuglandins:

21: Poliakov E, Brennan ML, Macpherson J, Zhang R, Sha W,
Narine L, Salomon RG, Hazen SL. Related Articles, Links
Isolevuglandins, a novel class of isoprostenoid
derivatives, function as integrated sensors of oxidant
stress and are generated by myeloperoxidase in vivo.
FASEB J. 2003 Dec;17(15):2209-20. PMID: 14656983 [PubMed
- indexed for MEDLINE]

22: Salomon RG, Kaur K, Batyreva E. Related Articles, Links
Isolevuglandin-protein adducts in oxidized low density
lipoprotein and human plasma: a strong connection with
cardiovascular disease. Trends Cardiovasc Med. 2000
Feb;10(2):53-9. Review. PMID: 11150730 [PubMed - indexed
for MEDLINE]

23: Salomon RG, Batyreva E, Kaur K, Sprecher DL, Schreiber
MJ, Crabb JW, Penn MS, DiCorletoe AM, Hazen SL, Podrez
EA. Related Articles, Links Isolevuglandin-protein
adducts in humans: products of free radical-induced lipid
oxidation through the isoprostane pathway. Biochim
Biophys Acta. 2000 May 31;1485(2-3):225-35. PMID:
10832102 [PubMed - indexed for MEDLINE]

24: Roberts LJ 2nd, Brame CJ, Chen Y, Morrow JD, Salomon RG.
Related Articles, Links Formation of reactive products of
the isoprostane pathway: isolevuglandins and
cyclopentenone isoprostanes. Adv Exp Med Biol.
1999;469:335-41. No abstract available. PMID: 10667350
[PubMed - indexed for MEDLINE]

25: Roberts LJ 2nd, Salomon RG, Morrow JD, Brame CJ. Related
Articles, Links New developments in the isoprostane
pathway: identification of novel highly reactive
gamma-ketoaldehydes (isolevuglandins) and
characterization of their protein adducts. FASEB J. 1999
Jul;13(10):1157-68. Review. PMID: 10385607 [PubMed -
indexed for MEDLINE]

26: Brame CJ, Salomon RG, Morrow JD, Roberts LJ 2nd.
Related Articles, Links Identification of extremely
reactive gamma-ketoaldehydes (isolevuglandins) as
products of the isoprostane pathway and
characterization of their lysyl protein adducts. J Biol
Chem. 1999 May 7;274(19):13139-46. PMID: 10224068
[PubMed - indexed for MEDLINE]

[Frank Roy]

Alf Christophersen wrote:

> On Mon, 2 Feb 2004 02:19:52 GMT, "John de Hoog"
> <dehoog@dehoog.org> wrote:
>
> >I'm surprised not to see B12 (as methylcobalamin, 500-1500
> >micrograms per day) and betaine. B12 works well with folic
> >acid to reduce homocysteine, and betaine has been shown to
> >reduce homocysteine dramatically.
>
> One problem with betaine is that it is quite osmotic active
> and activated aldose reductase which produce sorbitol from
> glucose in cells, which is also osmotic active and are very
> little mobile over membranes since it is sterically
> hindered to pass the Cl-regulated channel that do release
> taurine and beta-alanine when cell is volume or osmotically
> challenged (hypoosmosis), the increased sorbitol
> steady-state concentration if rate of turnover is not
> increased in parallell with synthesis will increase osmotic
> pressure inside and thus force taurine and betaine to leave
> cell thus making lack of protection against
> hyperhomocysteinamia and lack of protection against
> uncontrolled glycation, eg. by lysine of fructose to form
> an Amadori product 1-amino-1-deoxyfructose lysine adduct)
> which most possibly taurine may prevent to be formed by
> substituting lysine in the normal reaction since normally,
> taurine will be in great excess as free amino acid in cells
> (maybe one of the reasons intake of free amino acids may be
> hazardous, while intake of taurine is not dangerous at all
> since that will increase protection against formation of
> such derangeous products as AGEs.
>
> (There are several articles about taurine as glycation
> scavenger), but here you should read Nature, vol 414, p.
> 413ff, Michael Brownlee, Biochemistry and molecular cell
> biology of diabetic complications which doesn't mention one
> word about taurine, but taurine is kicked out of cell by
> mechanism 1 (several articles on cell volume regulation
> taurine as search word, while it protects against glycation
> products, it is involved in some phosporylations, and seem
> to protect against PKC activation.

I don't want to bull jive anyone into thinking I understand
this subject, but here are some further references.

The following article involves betaine transporters and
osmolytes. Betaine transporter cDNA cloning and effect of
osmolytes on its mRNA induction -
http://ajpcell.physiology.org/cgi/content/abstract/270/2/C650

Several of the references to this article also pertain to
betaine and taurine transporters. The following article also
discusses metabolism and transport of organic osmolytes such
as sorbitol, betaine, and inositol as well as osmotic
equilibriation.

"In some other epithelia, one of the physiological roles of
taurine, a ß-aminosulfonic acid, includes being a compatible
osmolyte. For example, in the Madin-Darby canine kidney (MDCK)
cell line, their taurine content increases twofold after a
rise in medium osmolality from 300 to 600 mosmol/kg. However,
it was not indicated whether the measured doubling of taurine
intracellular content was adequate for taurine to provide an
essential role as an osmolyte in restoring osmotic
equilibration between the internal and external milieu. Such
increases are known to be in part accountable for by
stimulation of a cell inward directed sodium- and
chloride-dependent taurine transporter. This transporter has
been identified in a host of epithelia and mediates
Na:Cl:taurine transport with a stoichiometric ratio of 2:1:1.
In MDCK cells and a rabbit renal papillary epithelial cell
line, adaptation to imposed hypertonic stress includes
transcription of genes that encode proteins (specific enzymes
and transporters) directly involved in the metabolism and
transport of organic osmolytes such as sorbitol, betaine, and
inositol."

"Three groups of osmolytes are used in mammalian cells:
polyalcohols, such as sorbitol and inositol; methylamines,
such as glycerophosphorylcholine and betaine; and amino acids
and amino acid derivatives, such as glycine, glutamine,
glutamate, aspartate, and taurine (141, 368, 370, 371, 629,
630, 714, 719, 724, 1077, 1381). Tissue-specific utilization
of the various osmolytes has been reviewed elsewhere in detail
(682)." Source: Functional Significance of Cell Volume
Regulatory Mechanisms -
http://physrev.physiology.org/cgi/content/full/78/1/247

"Mammalian cells utilize a wide variety of cell volume
regulatory mechanisms. For rapid adjustment of cell volume
cells release or accumulate ions through respective channels
and transport systems across the cell membrane. The most
widely used mechanisms of cell volume regulatory ion release
include ion channels and KCl symport. Ion uptake is most
frequently mediated by Na+ channels, Na+, K+, 2Cl-
cotransport, and Na+/H+ exchange. Chronic adjustment of cell
osmolarity is accomplished by the formation or accumulation of
organic osmolytes, molecules specifically designed to create
intracellular osmolarity without interfering with cellular
function. The most widely occurring osmolytes are sorbitol,
inositol, glycerophosphorylcholine, betaine, taurine, and
amino acids. The osmolytes are either synthesized by or
transported into shrunken cells. During cell swelling
osmolytes can be rapidly degraded or released. Any given cell
may utilize several volume-regulatory mechanisms. Moreover,
different mechanisms are utilized in different tissues. The
diversity of cell volume regulatory mechanisms allows the
cells to defend the constancy of cell volume against a myriad
of challenges with relatively little impairment of cellular
function." Source: The diversity of volume regulatory
mechanisms. - http://tinyurl.com/3cqdm

There are other articles co-authored by F. LANG and others on
topics of a similar vane cited in Functional Significance of
Cell Volume Regulatory Mechanisms -
http://physrev.physiology.org/cgi/content/full/78/1/247#B682.

For me it is an issue of whether to supplement with betaine
and if so at what level ?. What is the net impact on AGEs,
i.e., if you are supplementing with benfotiamine?

Frank