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Thu, Dec-25-03, 06:09
Arch Biochem Biophys. 2004 Jan 1;421(1):54-60. Related
Articles, Links
Antioxidants effectively prevent oxidation-induced protein
damage in OLN 93 cells.
Ernst A, Stolzing A, Sandig G, Grune T.
Neuroscience Research Center, Medical Faculty (Charite),
Humboldt University, Berlin, Germany
Oxidative stress is supposed to play an important role in
demyelinating diseases. Oligodendrocytes are the
myelin-forming cells in the brain and are highly susceptible
to oxidative stress due to their low antioxidative defense
systems and high metabolic rate. In the present work, we
tested the response of the oligodendrocyte cell line OLN 93 to
oxidative stress. OLN 93 cell cultures are characterized by a
loss of cell viability after oxidation. This loss of cell
viability is accompanied by an increase in protein oxidation
and consequently an elevated overall proteolysis. To minimize
the oxidative damage, we tested the effects of the
antioxidants alpha-lipoic acid and coenzyme Q(10). Both
compounds were able to elevate cell viability and to decrease
intracellular protein turnover and oxidant induced protein
oxidation. Therefore, we concluded that the excessive
oxidative damage of oligodendrocytes and their protein pool
can be prevented by the usage of antioxidants.
PMID: 14678784 [PubMed - in process]
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Articles, Links
Antioxidants effectively prevent oxidation-induced protein
damage in OLN 93 cells.
Ernst A, Stolzing A, Sandig G, Grune T.
Neuroscience Research Center, Medical Faculty (Charite),
Humboldt University, Berlin, Germany
Oxidative stress is supposed to play an important role in
demyelinating diseases. Oligodendrocytes are the
myelin-forming cells in the brain and are highly susceptible
to oxidative stress due to their low antioxidative defense
systems and high metabolic rate. In the present work, we
tested the response of the oligodendrocyte cell line OLN 93 to
oxidative stress. OLN 93 cell cultures are characterized by a
loss of cell viability after oxidation. This loss of cell
viability is accompanied by an increase in protein oxidation
and consequently an elevated overall proteolysis. To minimize
the oxidative damage, we tested the effects of the
antioxidants alpha-lipoic acid and coenzyme Q(10). Both
compounds were able to elevate cell viability and to decrease
intracellular protein turnover and oxidant induced protein
oxidation. Therefore, we concluded that the excessive
oxidative damage of oligodendrocytes and their protein pool
can be prevented by the usage of antioxidants.
PMID: 14678784 [PubMed - in process]
--------------------------------------------------------------
-------------
------
Who loves ya. Tom Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking