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Doe
Wed, Dec-24-03, 19:11
Occup Environ Med. 2004 Jan;61(1):82-5. Links

Total body iron overload in welder's siderosis.

Doherty MJ, Healy M, Richardson SG, Fisher NC.

Department of Respiratory Medicine, Dudley Group of Hospitals,
West Midlands, UK. Department of Haematology, Dudley Group of
Hospitals, West Midlands, UK. Department of Gastroenterology,
Dudley Group of Hospitals, West Midlands, UK.

Welder's siderosis occurs as a consequence of the inhalation
of iron dust. The iron overload of welder's siderosis is
usually considered to be confined to the lungs. Here we
present three proven cases of welder's siderosis associated
with evidence of increased total systemic iron stores, as
evidenced by increased serum ferritin levels. Multiple
investigations including molecular genotyping for the common
mutations found in genetic haemochromatosis failed to prove
this was due to haemochromatosis, nor was there any evidence
of any other recognised cause of systemic iron overload. Thus
the systemic iron overload described seems likely to be due to
either occupational exposure, an uncharacterised genetic
haemochromatosis, or a combination of both.

PMID: 14691279 [PubMed - in process]

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