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J Inorg Biochem. 2002 Apr 28;89(3-4):212-8. Related
Articles, Links
Aqueous and solid complexes of iron(III) with hyaluronic acid.
Potentiometric titrations and infrared spectroscopy studies.
Merce AL, Marques Carrera LC, Santos Romanholi LK, Lobo Recio
MA.
Departamento de Quimica, Universidade Federal do Parana, CP
19081, Centro Politecnico, Curitiba, 81531-990, Brazil.
anamerce@quimica.ufpr.br
The coordination of iron(III) ion to hyaluronic acid (Hyal) in
aqueous solutions and solid state was accomplished by
potentiometric titrations and infrared spectroscopy. The
potentiometric titration studies provided the binding
constants for the complexes found in the systems and the
speciation of these species according to the variation of pH
values. The complexes found presented a complexing ability
through both the chelating moieties of Hyal (via the
N-glucosamine and D-glucoronic acid), showing no special
preference for either one while in solid state, but when in
aqueous solution the complexation via the N-glucosamine moiety
was the preferred, forming two complexed species, ML and ML(2)
(log K(ML)=8.2 and log K(ML2)=7.9). The presence of a mu-oxo
complex via the D-glucoronic acid was also detected in both
aqueous (log K=6.7) and solid states via the N-glucosamine and
D-glucoronic acid simultaneously linked to two Hyal chains. A
structure for this latter complex was suggested. The results
indicated that these complexes could be used in eliminating
the excess iron(III) in living organisms.
PMID: 12062125 [PubMed - indexed for MEDLINE]
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Articles, Links
Aqueous and solid complexes of iron(III) with hyaluronic acid.
Potentiometric titrations and infrared spectroscopy studies.
Merce AL, Marques Carrera LC, Santos Romanholi LK, Lobo Recio
MA.
Departamento de Quimica, Universidade Federal do Parana, CP
19081, Centro Politecnico, Curitiba, 81531-990, Brazil.
anamerce@quimica.ufpr.br
The coordination of iron(III) ion to hyaluronic acid (Hyal) in
aqueous solutions and solid state was accomplished by
potentiometric titrations and infrared spectroscopy. The
potentiometric titration studies provided the binding
constants for the complexes found in the systems and the
speciation of these species according to the variation of pH
values. The complexes found presented a complexing ability
through both the chelating moieties of Hyal (via the
N-glucosamine and D-glucoronic acid), showing no special
preference for either one while in solid state, but when in
aqueous solution the complexation via the N-glucosamine moiety
was the preferred, forming two complexed species, ML and ML(2)
(log K(ML)=8.2 and log K(ML2)=7.9). The presence of a mu-oxo
complex via the D-glucoronic acid was also detected in both
aqueous (log K=6.7) and solid states via the N-glucosamine and
D-glucoronic acid simultaneously linked to two Hyal chains. A
structure for this latter complex was suggested. The results
indicated that these complexes could be used in eliminating
the excess iron(III) in living organisms.
PMID: 12062125 [PubMed - indexed for MEDLINE]
--------------------------------------------------------------
-------------
------
Who loves ya. Tom Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking