Mike
Thu, Aug-21-03, 19:12
1: Diabetes Res Clin Pract. 2003 Jul;61(1 Suppl):S9-S18.
Related Articles, Links
Pre-diabetes, insulin resistance, inflammation and CVD risk.
Haffner SM.
Department of Medicine, Division of Clinical Epidemiology,
University of Texas Health Science Center at San Antonio, DTL,
Room 5.606U, Mail code 7873, 7703 Floyd Curl Drive,
78229-3900, San Antonio, TX, USA
There is accumulating evidence that insulin resistance in the
pre-diabetic state is associated with the presence of
additional cardiovascular risk factors and increased incidence
of cardiovascular disease (CVD). There is also accumulating
evidence indicating that chronic sub-clinical inflammation as
measured by such inflammatory markers as C-reactive protein
(CRP) is associated with insulin resistance and other features
of the insulin resistance syndrome, increased risk of
development of type 2 diabetes and increased cardiovascular
event risk. Insulin-sensitizing agents may have greater
effects in reducing cardiovascular risk than secretagogues in
the pre-diabetic state, and glitazones have been found to
decrease CRP levels in patients with diabetes. Statins also
reduce CRP levels. Efforts to reduce CVD should include
increased emphasis on improving glycaemic control, preventing
development of diabetes and addressing cardiovascular risk
factors in the pre-diabetic state.
PMID: 12880690 [PubMed - in process]
2: Diabetes Res Clin Pract. 2003 Jul;61(1 Suppl):S9-S18.
Related Articles, Links
Pre-diabetes, insulin resistance, inflammation and CVD risk.
Haffner SM.
Department of Medicine, Division of Clinical Epidemiology,
University of Texas Health Science Center at San Antonio, DTL,
Room 5.606U, Mail code 7873, 7703 Floyd Curl Drive,
78229-3900, San Antonio, TX, USA
There is accumulating evidence that insulin resistance in the
pre-diabetic state is associated with the presence of
additional cardiovascular risk factors and increased incidence
of cardiovascular disease (CVD). There is also accumulating
evidence indicating that chronic sub-clinical inflammation as
measured by such inflammatory markers as C-reactive protein
(CRP) is associated with insulin resistance and other features
of the insulin resistance syndrome, increased risk of
development of type 2 diabetes and increased cardiovascular
event risk. Insulin-sensitizing agents may have greater
effects in reducing cardiovascular risk than secretagogues in
the pre-diabetic state, and glitazones have been found to
decrease CRP levels in patients with diabetes. Statins also
reduce CRP levels. Efforts to reduce CVD should include
increased emphasis on improving glycaemic control, preventing
development of diabetes and addressing cardiovascular risk
factors in the pre-diabetic state.
PMID: 12880690 [PubMed - in process]
Brief review @: http://www.docguide.com/news/content.nsf/Pape-
rFrameSet?OpenForm&refid=2&id=288CD03588170FAA8525695C0058883-
6&newsid=8525697700573E1885256D70003524FB&u=http://www.ncbi.n-
lm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abst-
ract&list_uids=12880690&ref=/ne
Shorter URL: http://makeashorterlink.com/?U206429A5
Anyone with evidence based insight care to comment?
MikeV
Related Articles, Links
Pre-diabetes, insulin resistance, inflammation and CVD risk.
Haffner SM.
Department of Medicine, Division of Clinical Epidemiology,
University of Texas Health Science Center at San Antonio, DTL,
Room 5.606U, Mail code 7873, 7703 Floyd Curl Drive,
78229-3900, San Antonio, TX, USA
There is accumulating evidence that insulin resistance in the
pre-diabetic state is associated with the presence of
additional cardiovascular risk factors and increased incidence
of cardiovascular disease (CVD). There is also accumulating
evidence indicating that chronic sub-clinical inflammation as
measured by such inflammatory markers as C-reactive protein
(CRP) is associated with insulin resistance and other features
of the insulin resistance syndrome, increased risk of
development of type 2 diabetes and increased cardiovascular
event risk. Insulin-sensitizing agents may have greater
effects in reducing cardiovascular risk than secretagogues in
the pre-diabetic state, and glitazones have been found to
decrease CRP levels in patients with diabetes. Statins also
reduce CRP levels. Efforts to reduce CVD should include
increased emphasis on improving glycaemic control, preventing
development of diabetes and addressing cardiovascular risk
factors in the pre-diabetic state.
PMID: 12880690 [PubMed - in process]
2: Diabetes Res Clin Pract. 2003 Jul;61(1 Suppl):S9-S18.
Related Articles, Links
Pre-diabetes, insulin resistance, inflammation and CVD risk.
Haffner SM.
Department of Medicine, Division of Clinical Epidemiology,
University of Texas Health Science Center at San Antonio, DTL,
Room 5.606U, Mail code 7873, 7703 Floyd Curl Drive,
78229-3900, San Antonio, TX, USA
There is accumulating evidence that insulin resistance in the
pre-diabetic state is associated with the presence of
additional cardiovascular risk factors and increased incidence
of cardiovascular disease (CVD). There is also accumulating
evidence indicating that chronic sub-clinical inflammation as
measured by such inflammatory markers as C-reactive protein
(CRP) is associated with insulin resistance and other features
of the insulin resistance syndrome, increased risk of
development of type 2 diabetes and increased cardiovascular
event risk. Insulin-sensitizing agents may have greater
effects in reducing cardiovascular risk than secretagogues in
the pre-diabetic state, and glitazones have been found to
decrease CRP levels in patients with diabetes. Statins also
reduce CRP levels. Efforts to reduce CVD should include
increased emphasis on improving glycaemic control, preventing
development of diabetes and addressing cardiovascular risk
factors in the pre-diabetic state.
PMID: 12880690 [PubMed - in process]
Brief review @: http://www.docguide.com/news/content.nsf/Pape-
rFrameSet?OpenForm&refid=2&id=288CD03588170FAA8525695C0058883-
6&newsid=8525697700573E1885256D70003524FB&u=http://www.ncbi.n-
lm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abst-
ract&list_uids=12880690&ref=/ne
Shorter URL: http://makeashorterlink.com/?U206429A5
Anyone with evidence based insight care to comment?
MikeV